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Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic miceOverexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph diseaseRNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph diseaseFibroblasts of Machado Joseph Disease patients reveal autophagy impairment.Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease.Overexpression of mutant ataxin-3 in mouse cerebellum induces ataxia and cerebellar neuropathology.Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease.
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researcher ORCID ID = 0000-0002-4937-448X
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0000-0002-4937-448X