pH-dependent permeabilization of the plasma membrane of mammalian cells by anthrax protective antigen
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Toxin-based therapeutic approachesIdentification of the cellular receptor for anthrax toxinDelayed toxicity associated with soluble anthrax toxin receptor decoy-Ig fusion protein treatmentPoint mutations in anthrax protective antigen that block translocation.Membrane insertion: The strategies of toxins (review).Activity of the Bacillus anthracis 20 kDa protective antigen component.Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis.The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigenSmall molecule inhibitors of anthrax toxin-induced cytotoxicity targeted against protective antigen.Designed azolopyridinium salts block protective antigen pores in vitro and protect cells from anthrax toxin.A Novel Chimeric Anti-PA Neutralizing Antibody for Postexposure Prophylaxis and Treatment of Anthrax.The adenylate cyclase toxins.Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating cytotoxin, reveals its pattern of assembly.Targeting HIV proteins to the major histocompatibility complex class I processing pathway with a novel gp120-anthrax toxin fusion proteinPhenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation.Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxinInhibition of Interleukin 1β (IL-1β) Expression by Anthrax Lethal Toxin (LeTx) Is Reversed by Histone Deacetylase 8 (HDAC8) Inhibition in Murine Macrophages.Anthrax toxin-induced rupture of artificial lipid bilayer membranes.Anthrax, toxins and vaccines: a 125-year journey targeting Bacillus anthracis.Sensitive fluorescence assay of anthrax protective antigen with two new DNA aptamers and their binding properties.The Mcf1 toxin induces apoptosis via the mitochondrial pathway and apoptosis is attenuated by mutation of the BH3-like domain.The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol.Alanine-scanning mutations in domain 4 of anthrax toxin protective antigen reveal residues important for binding to the cellular receptor and to a neutralizing monoclonal antibody.Bacterial protein toxins penetrate cells via a four-step mechanism.A dominant negative mutant of Bacillus anthracis protective antigen inhibits anthrax toxin action in vivo.Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha.Fluorescence resonance energy transfer studies on anthrax lethal toxin.The chaperone Hsp90 and PPIases of the cyclophilin and FKBP families facilitate membrane translocation of Photorhabdus luminescens ADP-ribosyltransferases.Purified Bacillus anthracis lethal toxin complex formed in vitro and during infection exhibits functional and biological activity.Molecular dynamics simulations of complexes between wild-type and mutant anthrax protective antigen variants and a model anthrax toxin receptor.Anthrax biosensor, protective antigen ion channel asymmetric blockade.Whole-cell voltage clamp measurements of anthrax toxin pore current.Clostridium botulinum C2 toxin: low pH-induced pore formation is required for translocation of the enzyme component C2I into the cytosol of host cells.Effect of Anthrax Toxin's Lethal Factor on Ion Channels Formed by the Protective Antigen
P2860
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P2860
pH-dependent permeabilization of the plasma membrane of mammalian cells by anthrax protective antigen
description
article
@en
im November 1993 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в листопаді 1993
@uk
name
pH-dependent permeabilization ...... by anthrax protective antigen
@en
pH-dependent permeabilization ...... by anthrax protective antigen
@nl
type
label
pH-dependent permeabilization ...... by anthrax protective antigen
@en
pH-dependent permeabilization ...... by anthrax protective antigen
@nl
prefLabel
pH-dependent permeabilization ...... by anthrax protective antigen
@en
pH-dependent permeabilization ...... by anthrax protective antigen
@nl
P2860
P1476
pH-dependent permeabilization ...... by anthrax protective antigen
@en
P2093
P2860
P304
P356
10.1111/J.1365-2958.1993.TB00936.X
P407
P577
1993-11-01T00:00:00Z