Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors

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Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors

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im Oktober 2018 veröffentlichter wissenschaftlicher Artikel

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wetenschappelijk artikel

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наукова стаття, опублікована в жовтні 2018

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Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors

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Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors

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Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors

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Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors

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Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors

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Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors

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P1476

Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors

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P2093

Alison P Hart

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Chiyang Lama

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Jacques J Kessl

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Jared D Hume

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Jian Sun

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Julie A Pigza

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Kaitlin A McNeely

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Nicholas G Jentsch

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P2860

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

A new class of multimerization selective inhibitors of HIV-1 integrase

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1

Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

P304

1007-1012

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P31

scholarly article

P356

10.1021/ACSMEDCHEMLETT.8B00269

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P407

English

P433

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P478

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P50

Matthew G Donahue

P577

2018-10-11T00:00:00Z

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P698

30344908

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P932

6187413

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