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Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug ResistanceClusters of isoleucine, leucine, and valine side chains define cores of stability in high-energy states of globular proteins: Sequence determinants of structure and stability.Machine learning integration for predicting the effect of single amino acid substitutions on protein stabilityStructural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 proteaseEvaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.Improving the Resistance Profile of Hepatitis C NS3/4A Inhibitors: Dynamic Substrate Envelope Guided DesignHIV-1 Protease and Substrate Coevolution Validates the Substrate Envelope As the Substrate Recognition Pattern.Drug-resistant HIV-1 protease regains functional dynamics through cleavage site coevolution.
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description
onderzoeker
@nl
researcher, ORCID id # 0000-0002-6240-1948
@en
name
Aysegul Ozen
@ast
Aysegul Ozen
@en
Aysegul Ozen
@es
Aysegul Ozen
@nl
type
label
Aysegul Ozen
@ast
Aysegul Ozen
@en
Aysegul Ozen
@es
Aysegul Ozen
@nl
prefLabel
Aysegul Ozen
@ast
Aysegul Ozen
@en
Aysegul Ozen
@es
Aysegul Ozen
@nl
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0000-0002-6240-1948