Improving the Resistance Profile of Hepatitis C NS3/4A Inhibitors: Dynamic Substrate Envelope Guided Design
about
Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172Comparative molecular dynamics simulation of Hepatitis C Virus NS3/4A protease (Genotypes 1b, 3a and 4b) predicts conformational instability of the catalytic triad in drug resistant strainsStructural analysis of asunaprevir resistance in HCV NS3/4A proteaseThe NS4A Cofactor Dependent Enhancement of HCV NS3 Protease Activity Correlates with a 4D Geometrical Measure of the Catalytic Triad Region.Interdependence of Inhibitor Recognition in HIV-1 Protease.Improving Viral Protease Inhibitors to Counter Drug Resistance.Identification of potential inhibitors for HCV NS3 genotype 4a by combining protein-ligand interaction fingerprint, 3D pharmacophore, docking, and dynamic simulation.Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease.Elucidating the Interdependence of Drug Resistance from Combinations of Mutations.Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants.Prediction of substrate specificity in NS3/4A serine protease by biased sequence search threading.
P2860
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P2860
Improving the Resistance Profile of Hepatitis C NS3/4A Inhibitors: Dynamic Substrate Envelope Guided Design
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Improving the Resistance Profi ...... bstrate Envelope Guided Design
@en
Improving the Resistance Profi ...... strate Envelope Guided Design.
@nl
type
label
Improving the Resistance Profi ...... bstrate Envelope Guided Design
@en
Improving the Resistance Profi ...... strate Envelope Guided Design.
@nl
prefLabel
Improving the Resistance Profi ...... bstrate Envelope Guided Design
@en
Improving the Resistance Profi ...... strate Envelope Guided Design.
@nl
P2860
P356
P1476
Improving the Resistance Profi ...... bstrate Envelope Guided Design
@en
P2093
Celia A Schiffer
Woody Sherman
P2860
P304
P356
10.1021/CT400603P
P50
P577
2013-12-01T00:00:00Z