about
Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformation.Epigenetics and cancer: altered chromatin remodeling via Snf5 loss leads to aberrant cell cycle regulation.SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex.Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry.Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors.TEL, a putative tumor suppressor, induces apoptosis and represses transcription of Bcl-XL.A mechanism for epigenetic control of DNA replication.
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description
researcher, ORCID id # 0000-0002-0253-8643
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wetenschapper
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name
Courtney G Sansam
@ast
Courtney G Sansam
@en
Courtney G Sansam
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type
label
Courtney G Sansam
@ast
Courtney G Sansam
@en
Courtney G Sansam
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prefLabel
Courtney G Sansam
@ast
Courtney G Sansam
@en
Courtney G Sansam
@nl
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P106
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0000-0002-0253-8643