SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity. - Wikidata - wikimedia - TriplyDB

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.

http://www.wikidata.org/entity/Q37262178

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SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions HP1 recruits activity-dependent neuroprotective protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers Genetic and Epigenetic Discoveries in Human Retinoblastoma Diverse roles and interactions of the SWI/SNF chromatin remodeling complex revealed using global approaches.BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression Methylation patterns of Brahma during spermatogenesis and oogenesis: potential implications.SNF5/INI1 deficiency redefines chromatin remodeling complex composition during tumor development.MITF-independent pro-survival role of BRG1-containing SWI/SNF complex in melanoma cells.Nuclear shape changes are induced by knockdown of the SWI/SNF ATPase BRG1 and are independent of cytoskeletal connections SWI/SNF complexes are required for full activation of the DNA-damage response.Mi-2/NuRD complex function is required for normal S phase progression and assembly of pericentric heterochromatin.SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma.The clinical significance of SWI/SNF complex in pancreatic cancer.BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss BAF complexes facilitate decatenation of DNA by topoisomerase IIα Chromatin Regulators as a Guide for Cancer Treatment Choice Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming.Regulation of transcription and chromatin structure by pRB: here, there and everywhere.CHD4 in the DNA-damage response and cell cycle progression: not so NuRDy now Roles of pRB in the Regulation of Nucleosome and Chromatin Structures.A novel retinoblastoma therapy from genomic and epigenetic analyses.Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability.The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4.Antioxidant N-acetylcysteine attenuates the reduction of Brg1 protein expression in the myocardium of type 1 diabetic rats.Comprehensive assessment of the expression of the SWI/SNF complex defines two distinct prognostic subtypes of ovarian clear cell carcinoma.CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models.Chromatin remodeling, BRCA1, SAHF and cellular senescence.Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer.Development of patient-specific neurons in schizophrenia using induced pluripotent stem cells.Use of clinical next-generation sequencing to identify melanomas harboring SMARCB1 mutations.Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies.Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies Mutational Landscapes and Phenotypic Spectrum of SWI/SNF-Related Intellectual Disability Disorders

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SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.

http://www.wikidata.org/entity/Q37262178

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article científic

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bilimsel makale

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scientific article published on 20 May 2009

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SWI/SNF deficiency results in ...... nished proliferative capacity.

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MBC.E08-12-1224

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Molecular Biology of the Cell

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SWI/SNF deficiency results in ...... nished proliferative capacity.

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Charles W M Roberts

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Christian Muchardt

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David Solomon

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Erik S Knudsen

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Hasan Siddiqui

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Moshe Yaniv

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Ryan J Bourgo

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Sejal Fox

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P2860

Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits

The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes

SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription

Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers

The ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesion

The yeast SNF2/SWI2 protein has DNA-stimulated ATPase activity required for transcriptional activation.

Reverse genetic analysis of the yeast RSC chromatin remodeler reveals a role for RSC3 and SNF5 homolog 1 in ploidy maintenance

Dissecting the regulatory circuitry of a eukaryotic genome

Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice

Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling

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3192-3199

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scholarly article

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10.1091/MBC.E08-12-1224

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14

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20

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Courtney G Sansam

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2009-05-20T00:00:00Z

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19458193

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2710832

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