about
The STIM1/Orai signaling machineryResting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cellsCooperativeness of Orai cytosolic domains tunes subtype-specific gating.A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 ChannelsIncreased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutantThe STIM/Orai coupling machinery.Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutantA calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription.Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.Recent progress on STIM1 domains controlling Orai activation.Cholesterol modulates Orai1 channel functionGating and permeation of Orai channels.Structure, regulation and biophysics of I(CRAC), STIM/Orai1.Molecular mechanisms of STIM/Orai communication.Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways.2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation.TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells.Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N-terminus.Communication between N-terminus and Loop2 tunes Orai activation.The STIM-Orai Pathway: The Interactions Between STIM and Orai.Rapid NMR-scale purification of 15N,13C isotope-labeled recombinant human STIM1 coiled coil fragments.CRAC inhibitors: identification and potentialSequential activation of STIM1 links Ca2+ with luminal domain unfoldingA novel STIM1-Orai1 gating interface essential for CRAC channel activationCritical parameters maintaining authentic CRAC channel hallmarks
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description
onderzoeker
@nl
researcher, ORCID id # 0000-0002-4768-146X
@en
name
Isabella Derler
@ast
Isabella Derler
@en
Isabella Derler
@es
Isabella Derler
@nl
type
label
Isabella Derler
@ast
Isabella Derler
@en
Isabella Derler
@es
Isabella Derler
@nl
prefLabel
Isabella Derler
@ast
Isabella Derler
@en
Isabella Derler
@es
Isabella Derler
@nl
P106
P21
P31
P496
0000-0002-4768-146X