Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant - Wikidata - wikimedia - TriplyDB

Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant

Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant

http://www.wikidata.org/entity/Q37372113

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STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation STIM proteins: dynamic calcium signal transducers Structural aspects of calcium-release activated calcium channel function Orai3--the 'exceptional' Orai?The STIM1/Orai signaling machinery Store-operated Orai channels: structure and function Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry Crystal Structure of the Calcium Release-Activated Calcium Channel Orai STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis Initial activation of STIM1, the regulator of store-operated calcium entry Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels.Exercise training decreases store-operated Ca2+entry associated with metabolic syndrome and coronary atherosclerosis.Molecular basis of calcium signaling in lymphocytes: STIM and ORAI Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1.STIM proteins and the endoplasmic reticulum-plasma membrane junctions.A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating.The N-terminal domain of Orai3 determines selectivity for activation of the store-independent ARC channel by arachidonic acid.Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.Competitive modulation of Ca2+ release-activated Ca2+ channel gating by STIM1 and 2-aminoethyldiphenyl borate Activation and regulation of store-operated calcium entry.Molecular biophysics of Orai store-operated Ca2+ channels.Orai1-mediated I (CRAC) is essential for neointima formation after vascular injury.STIM1 and Orai1: novel targets for vascular diseases?Molecular determinants within N terminus of Orai3 protein that control channel activation and gating.A STIM2 splice variant negatively regulates store-operated calcium entry.Store-operated calcium channels: new perspectives on mechanism and function.A basic sequence in STIM1 promotes Ca2+ influx by interacting with the C-terminal acidic coiled coil of Orai1.Store-operated calcium entry: Mechanisms and modulation.Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating.The STIM1-ORAI1 microdomain Activation of STIM1-Orai1 involves an intramolecular switching mechanism.Orai channel-mediated Ca2+ signals in vascular and airway smooth muscle.Orais and STIMs: physiological mechanisms and disease Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment.Molecular determinants mediating gating of Transient Receptor Potential Canonical (TRPC) channels by stromal interaction molecule 1 (STIM1).An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs.ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

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Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant

http://www.wikidata.org/entity/Q37372113

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 08 June 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Molecular determinants of the ...... by a STIM1 coiled-coil mutant

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Molecular determinants of the ...... by a STIM1 coiled-coil mutant.

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type

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Molecular determinants of the ...... by a STIM1 coiled-coil mutant

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Molecular determinants of the ...... by a STIM1 coiled-coil mutant.

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Molecular determinants of the ...... by a STIM1 coiled-coil mutant

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Molecular determinants of the ...... by a STIM1 coiled-coil mutant.

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JBC.M109.018408

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Journal of Biological Chemistry

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Molecular determinants of the ...... by a STIM1 coiled-coil mutant

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Judith Bergsmann

http://www.w3.org/2001/XMLSchema#string

Marc Fahrner

http://www.w3.org/2001/XMLSchema#string

Martin Muik

http://www.w3.org/2001/XMLSchema#string

P2860

Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry

Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity

Structural insight into KCNQ (Kv7) channel assembly and channelopathy

Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum.

STIM1, an essential and conserved component of store-operated Ca2+ channel function

Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry

STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction

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21696-21706

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scholarly article

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10.1074/JBC.M109.018408

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32

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284

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Christoph Romanin

Irene Frischauf

Isabella Derler

Klaus Groschner

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2009-06-08T00:00:00Z

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26275806

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19506081

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2755892

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