Intersectin-1s Regulates the Mitochondrial Apoptotic Pathway in Endothelial Cells
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Emerging roles for intersectin (ITSN) in regulating signaling and disease pathwaysRho GAPs and GEFs: controling switches in endothelial cell adhesionCalcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosisRegulation of neuron survival through an intersectin-phosphoinositide 3'-kinase C2beta-AKT pathwayIntersectin1-S, a multidomain adapter protein, is essential for malignant glioma proliferation.Impaired caveolae function and upregulation of alternative endocytic pathways induced by experimental modulation of intersectin-1s expression in mouse lung endothelium.Regulation of dynamin-2 assembly-disassembly and function through the SH3A domain of intersectin-1s.Multiple across-strain and within-strain QTLs suggest highly complex genetic architecture for hypoxia tolerance in channel catfish.Intersecting pathways in cell biologyPro-inflammatory endothelial cell dysfunction is associated with intersectin-1s down-regulation.Endocytic deficiency induced by ITSN-1s knockdown alters the Smad2/3-Erk1/2 signaling balance downstream of Alk5ITSN2L Interacts with and Negatively Regulates RABEP1.Intersectin 1 is required for neuroblastoma tumorigenesis.In vivo knockdown of intersectin-1s alters endothelial cell phenotype and causes microvascular remodeling in the mouse lungsMolecular determinants of endothelial transcytosis and their role in endothelial permeability.Long-term silencing of intersectin-1s in mouse lungs by repeated delivery of a specific siRNA via cationic liposomes. Evaluation of knockdown effects by electron microscopy.Tiam1 and Rac1 are required for platelet-activating factor-induced endothelial junctional disassembly and increase in vascular permeability.A novel p38 mitogen-activated protein kinase/Elk-1 transcription factor-dependent molecular mechanism underlying abnormal endothelial cell proliferation in plexogenic pulmonary arterial hypertensionITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1.Intersectin-2L regulates caveola endocytosis secondary to Cdc42-mediated actin polymerization.Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1.Identification of target genes for spermatogenic cell-specific KRAB transcription factor ZFP819 in a male germ cell line.Intersectin-1s: an important regulator of cellular and molecular pathways in lung injury.Intersectin scaffold proteins and their role in cell signaling and endocytosis.Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities.New insights into the functions of intersectin-1s.Intersectin-1s deficiency in pulmonary pathogenesisModulation of Intersectin-1s Lung Expression Induces Obliterative Remodeling and Severe Plexiform Arteriopathy in the Murine Pulmonary Vascular Bed.Neuregulin-1 suppresses cardiomyocyte apoptosis by activating PI3K/Akt and inhibiting mitochondrial permeability transition pore.Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets.Epsin15 Homology Domains: Role in the Pathogenesis of Pulmonary Arterial Hypertension
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Intersectin-1s Regulates the Mitochondrial Apoptotic Pathway in Endothelial Cells
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im April 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована у квітні 2007
@uk
name
Intersectin-1s Regulates the Mitochondrial Apoptotic Pathway in Endothelial Cells
@en
Intersectin-1s Regulates the Mitochondrial Apoptotic Pathway in Endothelial Cells
@nl
type
label
Intersectin-1s Regulates the Mitochondrial Apoptotic Pathway in Endothelial Cells
@en
Intersectin-1s Regulates the Mitochondrial Apoptotic Pathway in Endothelial Cells
@nl
prefLabel
Intersectin-1s Regulates the Mitochondrial Apoptotic Pathway in Endothelial Cells
@en
Intersectin-1s Regulates the Mitochondrial Apoptotic Pathway in Endothelial Cells
@nl
P2093
P2860
P356
P1476
Intersectin-1s Regulates the Mitochondrial Apoptotic Pathway in Endothelial Cells
@en
P2093
Asrar B. Malik
Dan N. Predescu
Irene K. Klein
Ivana Knezevic
Sanda A. Predescu
P2860
P304
17166-17178
P356
10.1074/JBC.M608996200
P407
P577
2007-04-03T00:00:00Z