Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities.
about
Emerging roles for intersectin (ITSN) in regulating signaling and disease pathwaysRegulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomesIntersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networksSelf-Organizing Feature Maps Identify Proteins Critical to Learning in a Mouse Model of Down SyndromeVesicle uncoating regulated by SH3-SH3 domain-mediated complex formation between endophilin and intersectin at synapsesImpaired caveolae function and upregulation of alternative endocytic pathways induced by experimental modulation of intersectin-1s expression in mouse lung endothelium.Regulation of dynamin-2 assembly-disassembly and function through the SH3A domain of intersectin-1s.Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampusFunctional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networksHypoxia-induced alternative splicing in endothelial cells.Intersecting pathways in cell biologyThe endocytic adaptor Eps15 controls marginal zone B cell numbersIntersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interactionIntersectin 1 is required for neuroblastoma tumorigenesis.Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.Presynaptic active zones in invertebrates and vertebrates.Fast neurotransmitter release regulated by the endocytic scaffold intersectin.Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis.Intersectin 1: a molecular linker in the central nervous system.Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome.Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase.RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase.Intersectin-1s: an important regulator of cellular and molecular pathways in lung injury.Exocytosis in non-neuronal cells.Intersectin scaffold proteins and their role in cell signaling and endocytosis.Serotonin-secreting enteroendocrine cells respond via diverse mechanisms to acute and chronic changes in glucose availability.Intersectin regulates dendritic spine development and somatodendritic endocytosis but not synaptic vesicle recycling in hippocampal neurons.The neuronal and endocrine roles of RCAN1 in health and disease.Fusion Pore Size Limits 5-HT Release From Single Enterochromaffin Cell Vesicles.Intersectin associates with synapsin and regulates its nanoscale localization and function.Modulation of Intersectin-1s Lung Expression Induces Obliterative Remodeling and Severe Plexiform Arteriopathy in the Murine Pulmonary Vascular Bed.Altered Expression of Intersectin1-L in Patients with Refractory Epilepsy and in Experimental Epileptic Rats.LRRK2(I2020T) functional genetic interactors that modify eye degeneration and dopaminergic cell loss in Drosophila.Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking.1.9 Mb microdeletion of 21q22.11 within Braddock-Carey contiguous gene deletion syndrome region: dissecting the phenotype.Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment.Sensing Exocytosis and Triggering Endocytosis at Synapses: Synaptic Vesicle Exocytosis-Endocytosis Coupling.
P2860
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P2860
Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Mice deficient for the chromos ...... cle-trafficking abnormalities.
@en
Mice deficient for the chromos ...... cle-trafficking abnormalities.
@nl
type
label
Mice deficient for the chromos ...... cle-trafficking abnormalities.
@en
Mice deficient for the chromos ...... cle-trafficking abnormalities.
@nl
prefLabel
Mice deficient for the chromos ...... cle-trafficking abnormalities.
@en
Mice deficient for the chromos ...... cle-trafficking abnormalities.
@nl
P2093
P2860
P50
P356
P1476
Mice deficient for the chromos ...... icle-trafficking abnormalities
@en
P2093
Damien J Keating
Daphne Dubach
Josephine Tkalcevic
Melanie A Pritchard
Po-Yin Chu
P2860
P304
P356
10.1093/HMG/DDN224
P577
2008-08-02T00:00:00Z