Self-association of PAR-3-mediated by the Conserved N-terminal Domain Contributes to the Development of Epithelial Tight Junctions - Wikidata - wikimedia - TriplyDB

Self-association of PAR-3-mediated by the Conserved N-terminal Domain Contributes to the Development of Epithelial Tight Junctions

Self-association of PAR-3-mediated by the Conserved N-terminal Domain Contributes to the Development of Epithelial Tight Junctions

http://www.wikidata.org/entity/Q58323630

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The PAR network: redundancy and robustness in a symmetry-breaking system Pard3 regulates contact between neural crest cells and the timing of Schwann cell differentiation but is not essential for neural crest migration or myelination.The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localization The Mammalian Blood-Testis Barrier: Its Biology and Regulation Junctional recruitment of mammalian Scribble relies on E-cadherin engagement Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice Signaling pathways in cell polarity.The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex.Par-3 controls tight junction assembly through the Rac exchange factor Tiam1.Widely conserved signaling pathways in the establishment of cell polarity Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells.Different domains of C. elegans PAR-3 are required at different times in development.Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation.Drosophila PATJ supports adherens junction stability by modulating Myosin light chain activity.Radial intercalation is regulated by the Par complex and the microtubule-stabilizing protein CLAMP/Spef1.Establishment of epithelial polarity--GEF who's minding the GAP?Identification of PDZK4, a novel human gene with PDZ domains, that is upregulated in synovial sarcomas.Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism Protein complexes that control renal epithelial polarity.PAR-3 oligomerization may provide an actin-independent mechanism to maintain distinct par protein domains in the early Caenorhabditis elegans embryo Bazooka/PAR3 is dispensable for polarity in Drosophila follicular epithelial cells The tight junction: a multifunctional complex.aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation.Association study between polymorphisms of the PARD3 gene and schizophrenia.Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity.Organization of multiprotein complexes at cell-cell junctions.The assembly and maintenance of epithelial junctions in C. elegans Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity.Loss of Par3 promotes lung adenocarcinoma metastasis through 14-3-3ζ protein.Cell polarity and asymmetric cell division: the C. elegans early embryo.PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion.sPAR-3, a splicing variant of PAR-3, shows cellular localization and an expression pattern different from that of PAR-3 during enterocyte polarization.aPKC Cycles between Functionally Distinct PAR Protein Assemblies to Drive Cell Polarity Protein clustering for cell polarity: Par-3 as a paradigm.The PAR proteins: from molecular circuits to dynamic self-stabilizing cell polarity.A Single-Cell Biochemistry Approach Reveals PAR Complex Dynamics during Cell Polarization.The protein kinase SIK downregulates the polarity protein Par3.Dynamic Opposition of Clustered Proteins Stabilizes Cortical Polarity in the C. elegans Zygote.Expressions of connexin and par-3 in the distal margin of rectal cancer after ultra-low anterior resection.Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair.

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Self-association of PAR-3-mediated by the Conserved N-terminal Domain Contributes to the Development of Epithelial Tight Junctions

http://www.wikidata.org/entity/Q58323630

description

article publié dans la revue scientifique Journal of Biological Chemistry

@fr

im Mai 2003 veröffentlichter wissenschaftlicher Artikel

@de

scientific article published in Journal of Biological Chemistry

@en

wetenschappelijk artikel

@nl

наукова стаття, опублікована в травні 2003

@uk

name

Self-association of PAR-3-medi ...... of Epithelial Tight Junctions

@en

Self-association of PAR-3-medi ...... of Epithelial Tight Junctions

@nl

type

label

Self-association of PAR-3-medi ...... of Epithelial Tight Junctions

@en

Self-association of PAR-3-medi ...... of Epithelial Tight Junctions

@nl

prefLabel

Self-association of PAR-3-medi ...... of Epithelial Tight Junctions

@en

Self-association of PAR-3-medi ...... of Epithelial Tight Junctions

@nl

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Journal of Biological Chemistry

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Self-association of PAR-3-medi ...... of epithelial tight junctions

@en

P2093

Atsushi Suzuki

http://www.w3.org/2001/XMLSchema#string

Keiko Mizuno

http://www.w3.org/2001/XMLSchema#string

Koichi Kitamura

http://www.w3.org/2001/XMLSchema#string

Koichi Kutsuzawa

http://www.w3.org/2001/XMLSchema#string

Masaaki Futaki

http://www.w3.org/2001/XMLSchema#string

Yoshiko Amano

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P2860

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures

Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C

Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)

Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins

An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3

A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation

Down-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomas

Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse

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31240-31250

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scholarly article

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10.1074/JBC.M303593200

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33

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278

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Tomonori Hirose

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2003-05-19T00:00:00Z

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P698

12756256

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