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A novel function for the survival motoneuron protein as a translational regulator

A novel function for the survival motoneuron protein as a translational regulator

http://www.wikidata.org/entity/Q58379271

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The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation Tracking fluctuation hotspots on the yeast ribosome through the elongation cycle Emerging therapies and challenges in spinal muscular atrophy The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly Identification and dynamic changes of RNAs isolated from RALY-containing ribonucleoprotein complexes.Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells The role of nuclear bodies in gene expression and disease.Presynaptic localization of Smn and hnRNP R in axon terminals of embryonic and postnatal mouse motoneurons Analysis of translation initiation during stress conditions by polysome profiling.Advances in therapeutic development for spinal muscular atrophy.Oligomeric Properties of Survival Motor Neuron·Gemin2 Complexes Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn (2b/-) mouse model of spinal muscular atrophy.Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons.Decreased function of survival motor neuron protein impairs endocytic pathways.A novel human-specific splice isoform alters the critical C-terminus of Survival Motor Neuron protein.eEF1Bγ binds the Che-1 and TP53 gene promoters and their transcripts.Spinal muscular atrophy: an update on therapeutic progress Dysregulation of mRNA Localization and Translation in Genetic Disease RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns.Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy.Developing therapies for spinal muscular atrophy.A novel role for CARM1 in promoting nonsense-mediated mRNA decay: potential implications for spinal muscular atrophy.Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes.Diverse role of survival motor neuron protein.Supraphysiological expression of survival motor neuron protein from an adenovirus vector does not adversely affect cell function.ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN.Spatially and temporally regulating translation via mRNA-binding proteins in cellular and neuronal function.Defects in pancreatic development and glucose metabolism in SMN-depleted mice independent of canonical spinal muscular atrophy neuromuscular pathology.Survival Motor Neuron Protein is Released from Cells in Exosomes: A Potential Biomarker for Spinal Muscular Atrophy.Regulation of Skeletal Muscle Plasticity by Protein Arginine Methyltransferases and Their Potential Roles in Neuromuscular Disorders.In Vivo Translatome Profiling in Spinal Muscular Atrophy Reveals a Role for SMN Protein in Ribosome Biology.Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron.HuD and the Survival Motor Neuron Protein Interact in Motoneurons and Are Essential for Motoneuron Development, Function, and mRNA Regulation.SMN regulation in SMA and in response to stress: new paradigms and therapeutic possibilities.Overview of Current Drugs and Molecules in Development for Spinal Muscular Atrophy Therapy.mRNP assembly, axonal transport, and local translation in neurodegenerative diseases.Solving the puzzle of spinal muscular atrophy: what are the missing pieces?Axon outgrowth and neuronal differentiation defects after a-SMN and FL-SMN silencing in primary hippocampal cultures.

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A novel function for the survival motoneuron protein as a translational regulator

http://www.wikidata.org/entity/Q58379271

description

im November 2012 veröffentlichter wissenschaftlicher Artikel

@de

scientific article published on 06 November 2012

@en

wetenschappelijk artikel

@nl

наукова стаття, опублікована в листопаді 2012

@uk

name

A novel function for the survival motoneuron protein as a translational regulator

@en

A novel function for the survival motoneuron protein as a translational regulator

@nl

type

label

A novel function for the survival motoneuron protein as a translational regulator

@en

A novel function for the survival motoneuron protein as a translational regulator

@nl

prefLabel

A novel function for the survival motoneuron protein as a translational regulator

@en

A novel function for the survival motoneuron protein as a translational regulator

@nl

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Human Molecular Genetics

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A novel function for the survival motoneuron protein as a translational regulator

@en

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Alain Y Dury

http://www.w3.org/2001/XMLSchema#string

Edouard W Khandjian

http://www.w3.org/2001/XMLSchema#string

Frédéric Charbonnier

http://www.w3.org/2001/XMLSchema#string

Gabriel Sanchez

http://www.w3.org/2001/XMLSchema#string

Helina Tadesse

http://www.w3.org/2001/XMLSchema#string

Lyndsay M Murray

http://www.w3.org/2001/XMLSchema#string

Olivier Biondi

http://www.w3.org/2001/XMLSchema#string

P2860

Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy

The Gemin5 protein of the SMN complex identifies snRNAs

RAP55, a cytoplasmic mRNP component, represses translation in Xenopus oocytes

Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes

The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins

Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing

Quantitative proteomics identifies Gemin5, a scaffolding protein involved in ribonucleoprotein assembly, as a novel partner for eukaryotic initiation factor 4E

SMN interacts with a novel family of hnRNP and spliceosomal proteins

miRNP:mRNA association in polyribosomes in a human neuronal cell line.

Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein.

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668-684

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scholarly article

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10.1093/HMG/DDS474

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4

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22

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Rachid El Fatimy

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2012-11-06T00:00:00Z

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23136128

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