Scratching the (cell) surface: cytokine engineering for improved ligand/receptor trafficking dynamics
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Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and ActivationInstructive roles for cytokine-receptor binding parameters in determining signaling and functional potencyHigh efficiency cell-specific targeting of cytokine activityA generic approach to engineer antibody pH-switches using combinatorial histidine scanning libraries and yeast displayTargeted erythropoietin selectively stimulates red blood cell expansion in vivo.Roles of transforming growth factor-alpha in mammary development and disease.Reengineering granulocyte colony-stimulating factor for enhanced stability.Increased endosomal sorting of ligand to recycling enhances potency of an interleukin-2 analog.Querying quantitative logic models (Q2LM) to study intracellular signaling networks and cell-cytokine interactionsRational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching".Integrating cell-level kinetic modeling into the design of engineered protein therapeutics.Development of prolactin receptor antagonists with reduced pH-dependence of receptor binding
P2860
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P2860
Scratching the (cell) surface: cytokine engineering for improved ligand/receptor trafficking dynamics
description
article
@en
наукова стаття, опублікована в жовтні 1998
@uk
name
Scratching the (cell) surface: ...... /receptor trafficking dynamics
@en
type
label
Scratching the (cell) surface: ...... /receptor trafficking dynamics
@en
prefLabel
Scratching the (cell) surface: ...... /receptor trafficking dynamics
@en
P1476
Scratching the (cell) surface: ...... /receptor trafficking dynamics
@en
P2093
D A Lauffenburger
E M Fallon
P304
P356
10.1016/S1074-5521(98)90110-7
P577
1998-10-01T00:00:00Z