Insights into the Structural Basis of the GADD45β-mediated Inactivation of the JNK Kinase, MKK7/JNKK2
about
Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitorsGADD45 proteins: central players in tumorigenesisThe crystal structure and dimerization interface of GADD45γTumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategiesGadd45 proteins as critical signal transducers linking NF-kappaB to MAPK cascadesNoise-induced changes in gene expression in the cochleae of mice differing in their susceptibility to noise damageDifferential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes.Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45BRedox regulation of tumor necrosis factor signalingGADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytesGadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling.Anti-Inflammatory Action of Insulin via Induction of Gadd45-β Transcription by the mTOR Signaling Pathway.Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45β-deficient miceGadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in miceExploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury.RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice.Gadd45b deficiency promotes premature senescence and skin aging.Mechanisms of liver disease: cross-talk between the NF-kappaB and JNK pathways.Knockdown of metallopanstimulin-1 inhibits NF-κB signaling at different levels: the role of apoptosis induction of gastric cancer cells.Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation.Insulin attenuates TNFα-induced hemopexin mRNA: An anti-inflammatory action of insulin in rat H4IIE hepatoma cells.Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis.GADD45β mediates p53 protein degradation via Src/PP2A/MDM2 pathway upon arsenite treatment.Harnessing downstream NF-κB signalling to achieve apoptosis-inducing anti-cancer-specific activity.Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression.Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver.Growth arrest and DNA damage protein 45b (Gadd45b) protects retinal ganglion cells from injuries.Probing the interaction interface of the GADD45β/MKK7 and MKK7/DTP3 complexes by chemical cross-linking mass spectrometry.Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity.
P2860
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P2860
Insights into the Structural Basis of the GADD45β-mediated Inactivation of the JNK Kinase, MKK7/JNKK2
description
2007 nî lūn-bûn
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2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Insights into the Structural B ...... of the JNK Kinase, MKK7/JNKK2
@en
Insights into the Structural B ...... of the JNK Kinase, MKK7/JNKK2
@en-gb
Insights into the Structural B ...... of the JNK Kinase, MKK7/JNKK2
@nl
type
label
Insights into the Structural B ...... of the JNK Kinase, MKK7/JNKK2
@en
Insights into the Structural B ...... of the JNK Kinase, MKK7/JNKK2
@en-gb
Insights into the Structural B ...... of the JNK Kinase, MKK7/JNKK2
@nl
prefLabel
Insights into the Structural B ...... of the JNK Kinase, MKK7/JNKK2
@en
Insights into the Structural B ...... of the JNK Kinase, MKK7/JNKK2
@en-gb
Insights into the Structural B ...... of the JNK Kinase, MKK7/JNKK2
@nl
P2093
P2860
P50
P356
P1476
Insights into the Structural B ...... of the JNK Kinase, MKK7/JNKK2
@en
P2093
Carlo Pedone
Kellean Alvarez
Menotti Ruvo
Nina Dathan
Rosa Maria Vitale
Shanthi Jayawardena
P2860
P304
19029-19041
P356
10.1074/JBC.M703112200
P407
P577
2007-05-07T00:00:00Z