Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats

about

An Update on the Synthesis of Pyrrolo[1,4]benzodiazepines Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours.From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).In vivo biotransformations of antibody-drug conjugates.

P2860

Q26772938-F88FD4DA-C8C4-4B06-9C26-F1A95E8ECFDA Q35748135-7D7F16A9-1B23-4314-B3A2-84217BF3C0FE Q37561359-9E323B6C-CC09-4463-9012-E04B47CB8764 Q38557525-B63D0F45-0761-45EC-8C91-B669A44BDA19

P2860

Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats

Item

http://www.wikidata.org/entity/Q58641838

description

im Dezember 2010 veröffentlichter wissenschaftlicher Artikel

@de

scientific article published on 28 December 2010

@en

wetenschappelijk artikel

@nl

наукова стаття, опублікована в грудні 2010

@uk

name

Pharmacokinetics, pharmacodyna ...... benzodiazepine SJG-136 in rats

@en

Pharmacokinetics, pharmacodyna ...... benzodiazepine SJG-136 in rats

@nl

type

Item

label

Pharmacokinetics, pharmacodyna ...... benzodiazepine SJG-136 in rats

@en

Pharmacokinetics, pharmacodyna ...... benzodiazepine SJG-136 in rats

@nl

prefLabel

Pharmacokinetics, pharmacodyna ...... benzodiazepine SJG-136 in rats

@en

Pharmacokinetics, pharmacodyna ...... benzodiazepine SJG-136 in rats

@nl

P1476

Pharmacokinetics, pharmacodyna ...... benzodiazepine SJG-136 in rats

@en

P2093

David E Thurston

http://www.w3.org/2001/XMLSchema#string

Joel M Reid

http://www.w3.org/2001/XMLSchema#string

John A Hartley

http://www.w3.org/2001/XMLSchema#string

Joseph E Tomaszewski

http://www.w3.org/2001/XMLSchema#string

Mary J Kuffel

http://www.w3.org/2001/XMLSchema#string

Matthew M Ames

http://www.w3.org/2001/XMLSchema#string

Sarah A Buhrow

http://www.w3.org/2001/XMLSchema#string

Victoria J Spanswick

http://www.w3.org/2001/XMLSchema#string

P2860

A public domain image-analysis program for the single-cell gel-electrophoresis (comet) assay

Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material

Cytochrome P-450 3A4: regulation and role in drug metabolism.

Cellular pharmacology of novel C8-linked anthramycin-based sequence-selective DNA minor groove cross-linking agents.

Cytochromes P-450 in rats: structures, functions, properties and relevant human forms.

The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links.

Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers.

The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill.

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations.

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.

P2888

s00280-010-1517-4

P304

777-786

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1007/S00280-010-1517-4

http://www.w3.org/2001/XMLSchema#string

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Lee Jia

P577

2010-12-28T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

21188379

http://www.w3.org/2001/XMLSchema#string

Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats

about

P2860

P2860

Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P433

P478

P50

P577

P698

P356

P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P433

P478

P50

P577

P698