The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links.
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Antibody-drug conjugates as novel anti-cancer chemotherapeuticsPyrrolobenzodiazepines (PBDs) do not bind to DNA G-quadruplexesCovalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA FragmentsChemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug ConjugatesOrchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair.Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours.From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepinesThe development of pyrrolobenzodiazepines as antitumour agents.From multiply active natural product to candidate drug? Antibacterial (and other) minor groove binders for DNA.Natural product and natural product derived drugs in clinical trials.Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agent.The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus.DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor AgentsHuman SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057.Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound libraryEffect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers.Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates.Inter- and intrastrand DNA crosslinks by 2-fluoro-substituted pyrrolobenzodiazepine dimers: stability, stereochemistry and drug orientation.Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug Conjugates.Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats
P2860
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P2860
The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
The pyrrolobenzodiazepine dime ...... on to interstrand cross-links.
@en
type
label
The pyrrolobenzodiazepine dime ...... on to interstrand cross-links.
@en
prefLabel
The pyrrolobenzodiazepine dime ...... on to interstrand cross-links.
@en
P2093
P356
P1476
The pyrrolobenzodiazepine dime ...... ion to interstrand cross-links
@en
P2093
Andrew S Thompson
Colin H James
David E Thurston
Mathangi Narayanaswamy
P304
13756-13766
P356
10.1021/JA902986X
P407
P577
2009-09-01T00:00:00Z