BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

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BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

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http://www.wikidata.org/entity/Q58696749

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im September 2018 veröffentlichter wissenschaftlicher Artikel

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wetenschappelijk artikel

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наукова стаття, опублікована у вересні 2018

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BRCA1 Mutation-Specific Respon ...... and PARP Inhibitor Resistance

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BRCA1 Mutation-Specific Respon ...... and PARP Inhibitor Resistance

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BRCA1 Mutation-Specific Respon ...... and PARP Inhibitor Resistance

@en

BRCA1 Mutation-Specific Respon ...... and PARP Inhibitor Resistance

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BRCA1 Mutation-Specific Respon ...... and PARP Inhibitor Resistance

@en

BRCA1 Mutation-Specific Respon ...... and PARP Inhibitor Resistance

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P1476

BRCA1 Mutation-Specific Respon ...... and PARP Inhibitor Resistance

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P2093

Alfonso Bellacosa

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Andre Nussenzweig

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Andrea J Bernhardy

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Dali Zong

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Daniela DiMarcantonio

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Elizabeth A Handorf

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Emma Clausen

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Emmanuelle Nicolas

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Esteban Martinez

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Gaorav P Gupta

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P2860

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

HELB Is a Feedback Inhibitor of DNA End Resection

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

Brca1 controls homology-directed DNA repair

P304

3513-3527.e7

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P31

scholarly article

P356

10.1016/J.CELREP.2018.08.086

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English

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P478

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P577

2018-09-25T00:00:00Z

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30257212

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P932

6219632

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