Discovery of New Inhibitors of Cdc25B Dual Specificity Phosphatases by Structure-Based Virtual Screening

Discovery of New Inhibitors of Cdc25B Dual Specificity Phosphatases by Structure-Based Virtual Screening

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http://www.wikidata.org/entity/Q58855705
Human TRIB2 Oscillates during the Cell Cycle and Promotes Ubiquitination and Degradation of CDC25CCDC25 Inhibition in Acute Myeloid Leukemia-A Study of Patient Heterogeneity and the Effects of Different Inhibitors.Phosphatases and kinases regulating CDC25 activity in the cell cycle: clinical implications of CDC25 overexpression and potential treatment strategiesSTAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemia.Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia--the possibility to target several kinases through inhibition of the various CDC25 isoforms.Emerging therapeutic targets for the treatment of human acute myeloid leukemia (part 1) - gene transcription, cell cycle regulation, metabolism and intercellular communication.Discovery of Cdc25A Lead Inhibitors with a Novel Chemotype by Virtual Screening: Application of Pharmacophore Modeling Based on a Training Set with a Limited Number of Unique Components.Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode.A novel inhibitor of Mammalian triosephosphate isomerase found by an in silico approach.Identification of the quinolinedione inhibitor binding site in Cdc25 phosphatase B through docking and molecular dynamics simulations.Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effect.CDC25A-inhibitory RE derivatives bind to pocket adjacent to the catalytic site.A novel oxybis cresol verticilatin with highly varying degrees of biological activities from the insect pathogenic fungus Paecilomyces verticillatus.
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Discovery of New Inhibitors of Cdc25B Dual Specificity Phosphatases by Structure-Based Virtual Screening

Item
http://www.wikidata.org/entity/Q58855705
description
im Mai 2012 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 01 May 2012
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в травні 2012
@uk
name
Discovery of New Inhibitors of ...... ucture-Based Virtual Screening
@en
Discovery of New Inhibitors of ...... ucture-Based Virtual Screening
@nl
type
label
Discovery of New Inhibitors of ...... ucture-Based Virtual Screening
@en
Discovery of New Inhibitors of ...... ucture-Based Virtual Screening
@nl
prefLabel
Discovery of New Inhibitors of ...... ucture-Based Virtual Screening
@en
Discovery of New Inhibitors of ...... ucture-Based Virtual Screening
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
Discovery of new inhibitors of ...... ucture-based virtual screening
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698