11-Beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors in Type 2 diabetes mellitus and obesity
about
Investigational anti-hyperglycemic agents: the future of type 2 diabetes therapy?Ketoconazole enantiomer for the treatment of diabetes mellitus.11β-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus.Increased skeletal muscle 11βHSD1 mRNA is associated with lower muscle strength in ageing.Discovery of adamantyl heterocyclic ketones as potent 11β-hydroxysteroid dehydrogenase type 1 inhibitorsAdamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1Decreased 11β-Hydroxysteroid Dehydrogenase 1 Level and Activity in Murine Pancreatic Islets Caused by Insulin-Like Growth Factor I Overexpression.Impaired oxidoreduction by 11β-hydroxysteroid dehydrogenase 1 results in the accumulation of 7-oxolithocholic acid.11beta-hydroxysteroid dehydrogenase type 1 inhibitors: a review of recent patents.Glucocorticoids and renal Na+ transport: implications for hypertension and salt sensitivity.Diabetes area participation analysis: a review of companies and targets described in the 2008 - 2010 patent literature.Crystal structures of 11β-hydroxysteroid dehydrogenase type 1 and their use in drug discovery.Metabolic syndrome in patients with hematological diseases.Circadian rhythms in liver physiology and liver diseases.Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1.Potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 labeled with carbon-13 and carbon-14.Labisia pumila extract down-regulates hydroxysteroid (11-beta) dehydrogenase 1 expression and corticosterone levels in ovariectomized rats.
P2860
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P2860
11-Beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors in Type 2 diabetes mellitus and obesity
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
11-Beta-hydroxysteroid dehydro ...... diabetes mellitus and obesity
@en
11-Beta-hydroxysteroid dehydrogenase type 1
@nl
type
label
11-Beta-hydroxysteroid dehydro ...... diabetes mellitus and obesity
@en
11-Beta-hydroxysteroid dehydrogenase type 1
@nl
prefLabel
11-Beta-hydroxysteroid dehydro ...... diabetes mellitus and obesity
@en
11-Beta-hydroxysteroid dehydrogenase type 1
@nl
P2093
P2860
P1476
11-Beta-hydroxysteroid dehydro ...... diabetes mellitus and obesity
@en
P2093
Brian R Walker
Katherine A Hughes
Scott P Webster
P2860
P304
P356
10.1517/13543784.17.4.481
P407
P577
2008-03-25T00:00:00Z