Mobile reactive centre of serpins and the control of thrombosis
about
The anticoagulant activation of antithrombin by heparinMechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactionsPlasminogen-activator inhibitor type 2 (PAI-2) is a spontaneously polymerising SERPIN. Biochemical characterisation of the recombinant intracellular and extracellular formsThe profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis Cleaves and inactivates plasminogen activator inhibitor type 1.The effects of reactive site location on the inhibitory properties of the serpin alpha(1)-antichymotrypsin.Non-muscle alpha-actinin-4 interacts with plasminogen activator inhibitor type-1 (PAI-1).What do dysfunctional serpins tell us about molecular mobility and disease?C1 inhibitor hinge region mutations produce dysfunction by different mechanisms.The Z type variation of human alpha 1-antitrypsin causes a protein folding defect.Latent antithrombin and its detection, formation and turnover in the circulation.Serpins in rice: protein sequence analysis, phylogeny and gene expression during development.Blocking formation of large protein aggregates by small peptides.A novel mode of polymerization of alpha1-proteinase inhibitor.Mixture-based combinatorial libraries from small individual peptide libraries: a case study on α1-antitrypsin deficiency.Mechanisms of glycosaminoglycan activation of the serpins in hemostasis.What we owe to alpha(1)-antitrypsin and to Carl-Bertil Laurell.Limitations of conventional anticoagulant therapy and the promises of non-heparin based conformational activators of antithrombin.Characterization of N-linked oligosaccharides attached to recombinant human antithrombin expressed in the yeast Pichia pastoris.Purification of a modified form of bovine antithrombin III as an HIV-1 CD8+ T-cell antiviral factor.Partial activation of antithrombin without heparin through deletion of a unique sequence on the reactive site loop of the serpin.The biostructural pathology of the serpins: critical function of sheet opening mechanism.COOH-terminal substitutions in the serpin C1 inhibitor that cause loop overinsertion and subsequent multimerization.Review: alpha 1-antitrypsin deficiency associated liver disease.Protein folding in the landscape perspective: chevron plots and non-Arrhenius kinetics.Effects of acrolein, a natural occurring aldehyde, on the anticoagulant serpin antithrombin.Electrophoretic characterization of heat-stable squamous cell carcinoma antigen.Regulation of glycosaminoglycan function by osmotic potentials. Measurement of water transfer during antithrombin activation by heparin.High level expression of recombinant human antithrombin in the mammary gland of rabbits by adenoviral vectors infection.Protonation state of a single histidine residue contributes significantly to the kinetics of the reaction of plasminogen activator inhibitor-1 with tissue-type plasminogen activator.Proteolytically cleaved mutant antithrombin-Hamilton has high stability to denaturation characteristic of wild type inhibitor serpins.Thermostability of refolded ovalbumin and S-ovalbumin.Antithrombin-TRI (Ala382 to Thr) causing severe thromboembolic tendency undergoes the S-to-R transition and is associated with a plasma-inactive high-molecular-weight complex of aggregated antithrombin.Thermostabilization of ovalbumin by an alkaline treatment: examination for the possible implications of an altered serpin loop structure.The acid stabilization of plasminogen activator inhibitor-1 depends on protonation of a single group that affects loop insertion into beta-sheet A.A specific structural interaction of Alzheimer's peptide A beta 1-42 with alpha 1-antichymotrypsin.In vitro amyloid fibril formation from alpha 1-antitrypsin.Successive action of Escherichia coli chaperones in vivo.
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Mobile reactive centre of serpins and the control of thrombosis
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в жовтні 1991
@uk
name
Mobile reactive centre of serpins and the control of thrombosis
@en
Mobile reactive centre of serpins and the control of thrombosis
@nl
type
label
Mobile reactive centre of serpins and the control of thrombosis
@en
Mobile reactive centre of serpins and the control of thrombosis
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prefLabel
Mobile reactive centre of serpins and the control of thrombosis
@en
Mobile reactive centre of serpins and the control of thrombosis
@nl
P2093
P356
P1433
P1476
Mobile reactive centre of serpins and the control of thrombosis
@en
P2093
P2888
P304
P356
10.1038/353576A0
P407
P577
1991-10-01T00:00:00Z
P6179
1031775725