The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions
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Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinasesProbing serpin reactive-loop conformations by proteolytic cleavageCrystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)The anticoagulant activation of antithrombin by heparinCrystal structure of monomeric native antithrombin reveals a novel reactive center loop conformationPepsin-inhibitory activity of the uterine serpinsCrystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibitionThe conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regionsTopography of a 2.0 Å structure of α1-antitrypsin reveals targets for rational drug design to prevent conformational diseaseCrystal structure of the complex of plasminogen activator inhibitor 2 with a peptide mimicking the reactive center loopCrystal structure of neuroserpin: a neuronal serpin involved in a conformational diseaseSerpin polymerization is prevented by a hydrogen bond network that is centered on his-334 and stabilized by glycerolThe influence of hinge region residue Glu-381 on antithrombin allostery and metastabilityStructural and Functional Characterization of a Highly Specific Serpin in the Insect Innate ImmunityStructure of an Engineered β-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric RegulationCrystal structure of an uncleaved alpha 1-antitrypsin reveals the conformation of its inhibitory reactive loopThe molecular interactions of heat shock protein 47 (Hsp47) and their implications for collagen biosynthesisStructure of a serpin-enzyme complex probed by cysteine substitutions and fluorescence spectroscopy.The role of strand 1 of the C beta-sheet in the structure and function of alpha(1)-antitrypsinThe anti-angiogenic peptide anginex disrupts the cell membrane.A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin.Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.From natural to synthetic multisite thrombin inhibitors.Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin.Hydration structure of antithrombin conformers and water transfer during reactive loop insertionHydration effects of heparin on antithrombin probed by osmotic stress.Allosteric activation of antithrombin critically depends upon hinge region extension.The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2.Structural and inhibitory effects of hinge loop mutagenesis in serpin-2 from the malaria vector Anopheles gambiae.A novel mode of polymerization of alpha1-proteinase inhibitor.ANISERP: a new serpin from the parasite Anisakis simplex.CLT1 targets angiogenic endothelium through CLIC1 and fibronectin.Crystal structure analyses of uncomplexed ecotin in two crystal forms: implications for its function and stability.Serpin alpha 1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopyInteraction of subtilisins with serpinsStructural investigation of the alpha-1-antichymotrypsin: prostate-specific antigen complex by comparative model buildingMolecular evolution of plasminogen activator inhibitor-1 functional stabilityIdentification of tissue-type plasminogen activator-specific plasminogen activator inhibitor-1 mutants. Evidence that second sites of interaction contribute to target specificity.
P2860
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P2860
The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
The intact and cleaved human a ...... serpin-proteinase interactions
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The intact and cleaved human a ...... serpin-proteinase interactions
@en
The intact and cleaved human a ...... serpin-proteinase interactions
@nl
type
label
The intact and cleaved human a ...... serpin-proteinase interactions
@ast
The intact and cleaved human a ...... serpin-proteinase interactions
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The intact and cleaved human a ...... serpin-proteinase interactions
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prefLabel
The intact and cleaved human a ...... serpin-proteinase interactions
@ast
The intact and cleaved human a ...... serpin-proteinase interactions
@en
The intact and cleaved human a ...... serpin-proteinase interactions
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P2093
P2860
P356
P1476
The intact and cleaved human a ...... serpin-proteinase interactions
@en
P2093
H A Schreuder
H J Theunissen
P D Grootenhuis
P2860
P356
10.1038/NSB0194-48
P577
1994-01-01T00:00:00Z