about
SH2-Bbeta is a Rac-binding protein that regulates cell motilityJAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functionsPAK1-Nck regulates cyclin D1 promoter activity in response to prolactinYXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.Src tyrosyl phosphorylates cortactin in response to prolactin.Adapter protein SH2-Bbeta stimulates actin-based motility of Listeria monocytogenes in a vasodilator-stimulated phosphoprotein (VASP)-dependent fashion.Tyrosyl phosphorylated PAK1 regulates breast cancer cell motility in response to prolactin through filamin APAK1 translocates into nucleus in response to prolactin but not to estrogen.Prolactin-induced PAK1 tyrosyl phosphorylation promotes FAK dephosphorylation, breast cancer cell motility, invasion and metastasis.Adapter protein SH2B1beta cross-links actin filaments and regulates actin cytoskeletonInvestigating the role of Aurora kinases in RAS signaling.SH2-B is required for growth hormone-induced actin reorganization.
P50
Q28215233-5402A337-EB6B-4D6A-A345-AE57D35EAA31Q28242536-C5B0B3DB-3717-4072-9B2B-03A199ED98ADQ30425265-C0EB0286-D2F7-4175-BF5A-27B195E81936Q34173102-83FAD216-AE17-4B8C-BE63-EC52AF4F4641Q35836464-2FFFCF30-5835-494A-B9BE-B91D242BB85DQ35913642-4838C225-E0C1-46A1-AEA7-F316712DF0E7Q36660604-08A1F291-B608-4EE0-9843-3E6016397E03Q36813554-0803D2B9-47DC-4E5A-88D2-5FD07066901CQ37192218-3C28E2B4-7069-4947-9BC2-4F4924B398F0Q37244857-0F66FFB4-913D-4233-A13C-C70C6B604335Q39916809-3CC401DD-DF17-435B-9DB8-AE6D45494CE9Q42802819-67313DB4-6650-45E9-A07F-8238C53B6802
P50
description
researcher ORCID ID = 0000-0002-4554-2730
@en
wetenschapper
@nl
name
Maria Diakonova
@ast
Maria Diakonova
@en
Maria Diakonova
@es
Maria Diakonova
@nl
type
label
Maria Diakonova
@ast
Maria Diakonova
@en
Maria Diakonova
@es
Maria Diakonova
@nl
prefLabel
Maria Diakonova
@ast
Maria Diakonova
@en
Maria Diakonova
@es
Maria Diakonova
@nl
P1153
6602962281
P21
P31
P496
0000-0002-4554-2730