about
AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesteraseEarly receptor current of wild-type and transducin knockout mice: photosensitivity and light-induced Ca2+ releaseThe Y99C mutation in guanylyl cyclase-activating protein 1 increases intracellular Ca2+ and causes photoreceptor degeneration in transgenic mice.Time course and magnitude of the calcium release induced by bright light in salamander rods.Light-dependent changes in outer segment free-Ca2+ concentration in salamander cone photoreceptors.Bleached pigment produces a maintained decrease in outer segment Ca2+ in salamander rodsBackground light produces a recoverin-dependent modulation of activated-rhodopsin lifetime in mouse rods.Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate.Light, Ca2+, and photoreceptor death: new evidence for the equivalent-light hypothesis from arrestin knockout mice.Light-induced calcium release and re-uptake in toad rods.GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase.Adaptation in vertebrate photoreceptors.Dark adaptation.Single-photon sensitivity of lamprey rods with cone-like outer segments.Rhodopsin kinase and recoverin modulate phosphodiesterase during mouse photoreceptor light adaptation.Effect of the ILE86TER mutation in the γ subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling.Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironmentHow rods respond to single photons: Key adaptations of a G-protein cascade that enable vision at the physical limit of perception.Why photoreceptors die (and why they don't).Ca2+-dependent changes in cyclic GMP levels are not correlated with opening and closing of the light-dependent permeability of toad photoreceptors.Persistent activation of transducin by bleached rhodopsin in salamander rods.Night blindness and the mechanism of constitutive signaling of mutant G90D rhodopsinConstitutive excitation by Gly90Asp rhodopsin rescues rods from degeneration caused by elevated production of cGMP in the dark.Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q).Detection of single photons by toad and mouse rods.Modulation of phosphodiesterase6 turnoff during background illumination in mouse rod photoreceptors.Modulation of mouse rod photoreceptor responses by Grb14 protein.Starburst amacrine cells change from spiking to nonspiking neurons during retinal developmentPhototransduction and the evolution of photoreceptors.Adaptation of mammalian photoreceptors to background light: putative role for direct modulation of phosphodiesterase.The evolution of rod photoreceptors.Mechanisms of synaptic transmission in the retina.Dark adaptation in vertebrate photoreceptors.Cambrian origin of the CYP27C1-mediated vitamin A1-to-A2 switch, a key mechanism of vertebrate sensory plasticity.Support for the equivalent light hypothesis for RP.Physiological studies of the interaction between opsin and chromophore in rod and cone visual pigments.Knockout of GARPs and the β-subunit of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrity.Effect of knocking down the insulin receptor on mouse rod responses.ATP consumption by mammalian rod photoreceptors in darkness and in light.Calcium in dark-adapted toad rods: evidence for pooling and cyclic-guanosine-3'-5'-monophosphate-dependent release.
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description
researcher ORCID ID = 0000-0002-9813-0342
@en
wetenschapper
@nl
name
Gordon L Fain
@ast
Gordon L Fain
@en
Gordon L Fain
@nl
type
label
Gordon L Fain
@ast
Gordon L Fain
@en
Gordon L Fain
@nl
prefLabel
Gordon L Fain
@ast
Gordon L Fain
@en
Gordon L Fain
@nl
P106
P31
P496
0000-0002-9813-0342