about
Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitorsStructural determination of estrogen-related receptor gamma in the presence of phenol derivative compoundsStructural basis for elastolytic substrate specificity in rodent alpha-chymasesPotent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivativesPotency variation of small-molecule chymase inhibitors across speciesStructural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutesOutcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.Fragment screening purely with protein crystallography.Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation.Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif.Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors.Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors.A novel series of potent and selective small molecule inhibitors of the complement component C1s.Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif.Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors.6-Substituted quinolines as RORγt inverse agonists.Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt.Identification and biological evaluation of thiazole-based inverse agonists of RORγt.Inhibition of matrix metalloproteinases by hydroxamates containing heteroatom-based modifications of the P1' groupAmidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitorsStructure-activity and crystallographic analysis of a new class of non-amide-based thrombin inhibitorIn vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitorsCrystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors
P50
Q27642154-3C3910FA-438E-4350-9899-6EFCA35E522EQ27648429-B9F125C6-8DD6-48C8-A32E-ACBB1708FA1BQ27648912-BBA12B01-1619-443D-8898-1155A006A948Q27648954-9A23CD33-0A0D-488B-B19A-1D468EE031DDQ27649846-85FF43BF-C9C5-4FE6-964F-31ECB3AC1317Q27663012-D66BEC87-ADB8-4E5F-A16D-A93E6174A592Q27758627-C000715D-BA58-4E6F-8034-7B0B87B7431EQ30277026-D70ECD18-C631-45AD-AF68-3086C17EB16EQ33211997-57E45380-F9E6-436E-857D-7D9ADD042D48Q33836437-875C1AD1-0689-4954-A774-1C03FE32C7FCQ38634770-6A683D47-8CE3-4D6D-8DC0-650838EA9723Q43184037-1A39018C-5E70-437C-B148-7DBD53FA7EB4Q43569166-41DAC8F3-A98F-4C54-9F6E-AC3D88B90B13Q43621522-FE1F569F-2BDF-448D-BA76-7FB8046EE8ABQ44900634-0C8B0F93-EA14-41E6-B4A7-5E227C267DCCQ46638571-223FA7D1-C008-4843-BF73-A861BF36345FQ46763506-AD7336E5-B7F9-46E5-9F02-9A3EA4843956Q47593106-419FB9D3-D469-4190-9701-FFBFD9ADEC71Q51093763-5BDC9AA2-B496-418F-B42A-40295E45F29EQ52597991-63E44590-03B9-4BA6-A027-8C0728557595Q71943787-DDD866F7-7048-460F-9521-114B3855522EQ73356217-3247913E-0B37-4F3D-99EB-76D2A63E5480Q73356269-E5349C58-D0FA-4B71-98C2-730E11942301Q77748895-375A95DA-02A6-454A-8D17-FB6725FAB62AQ79389649-DC188DC4-F602-432F-B507-9D63D7593D10
P50
description
researcher ORCID ID = 0000-0003-1308-2570
@en
wetenschapper
@nl
name
John Spurlino
@ast
John Spurlino
@en
John Spurlino
@es
John Spurlino
@nl
type
label
John Spurlino
@ast
John Spurlino
@en
John Spurlino
@es
John Spurlino
@nl
prefLabel
John Spurlino
@ast
John Spurlino
@en
John Spurlino
@es
John Spurlino
@nl
P106
P1153
6603728094
P31
P496
0000-0003-1308-2570