Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells. - Wikidata - wikimedia - TriplyDB

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

http://www.wikidata.org/entity/Q33211997

about

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy The structural basis of arrestin-mediated regulation of G-protein-coupled receptors Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer.Chemical Variations on the p53 Reactivation Theme Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions Elucidation of Ligand-Dependent Modulation of Disorder-Order Transitions in the Oncoprotein MDM2 Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX Using a Fragment-Based Approach To Target Protein-Protein Interactions Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53 Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant Protein grafting of p53TAD onto a leucine zipper scaffold generates a potent HDM dual inhibitor The p53 pathway as a target in cancer therapeutics: obstacles and promise The role of p53 in cancer drug resistance and targeted chemotherapy Molecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple Myeloma Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness mRNA Display Selection of an Optimized MDM2-Binding Peptide That Potently Inhibits MDM2-p53 Interaction Simulating molecular mechanisms of the MDM2-mediated regulatory interactions: a conformational selection model of the MDM2 lid dynamics Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists Modeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable.What can we learn from the evolution of protein-ligand interactions to aid the design of new therapeutics?Probing Difference in Binding Modes of Inhibitors to MDMX by Molecular Dynamics Simulations and Different Free Energy Methods Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction A Strategy for Direct Chemical Activation of the Retinoblastoma Protein Therapeutic considerations for Mdm2: not just a one trick pony Patented small molecule inhibitors in the ubiquitin proteasome system Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.Targeting p53 for Novel Anticancer Therapy.Privileged diazepine compounds and their emergence as bromodomain inhibitors.Chemical genetics.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases A computational analysis of the binding model of MDM2 with inhibitors.Design and Synthesis of Functionalized Trisaccharides as p53-Peptide Mimics.Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins In silico identification of an interferon inhibitor.Application of a sequential multicomponent assembly process/huisgen cycloaddition strategy to the preparation of libraries of 1,2,3-triazole-fused 1,4-benzodiazepines.From laptop to benchtop to bedside: structure-based drug design on protein targets.

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P2860

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

http://www.wikidata.org/entity/Q33211997

description

2005 nî lūn-bûn

@nan

2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի փետրվարին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Discovery and cocrystal struct ...... ts that activate p53 in cells.

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Discovery and cocrystal struct ...... ts that activate p53 in cells.

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type

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Discovery and cocrystal struct ...... ts that activate p53 in cells.

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Discovery and cocrystal struct ...... ts that activate p53 in cells.

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prefLabel

Discovery and cocrystal struct ...... ts that activate p53 in cells.

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Discovery and cocrystal struct ...... ts that activate p53 in cells.

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P1433

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Journal of Medicinal Chemistry

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Discovery and cocrystal struct ...... sts that activate p53 in cells

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Anna C Maroney

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Bruce E Tomczuk

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Bruce L Grasberger

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Carl L Manthey

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Carol F Franks

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Carsten Schubert

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Daniel J Parks

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Diane Maguire

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Eugene C Petrella

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Gwendolyn R Bylebyl

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909-912

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scholarly article

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10.1021/JM049137G

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4

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48

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Christopher J. Molloy

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2005-02-01T00:00:00Z

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8018622

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15715460

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