about
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminaseB1b lymphocytes confer T cell-independent long-lasting immunityAberrant expansion of segmented filamentous bacteria in IgA-deficient gutAID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylaseA target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expressionHistone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination.Negative regulation of activation-induced cytidine deaminase in B cellsMolecular mechanism of class switch recombination: linkage with somatic hypermutation.PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in miceDe novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.AID: how does it aid antibody diversity?AID to overcome the limitations of genomic information.AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements.RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminaseRNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cellsDiscovery of activation-induced cytidine deaminase, the engraver of antibody memory.Carboxy-terminal domain of AID required for its mRNA complex formation in vivo.De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination.Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.Unmutated immunoglobulin M can protect mice from death by influenza virus infection.AID mutant analyses indicate requirement for class-switch-specific cofactors.AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts.The AID enzyme induces class switch recombination in fibroblasts.Separate domains of AID are required for somatic hypermutation and class-switch recombination.Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation.DNA double-strand breaks: prior to but not sufficient in targeting hypermutation.Constitutive expression of AID leads to tumorigenesis.Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora.AID is required for c-myc/IgH chromosome translocations in vivo.Low-affinity IgM antibodies lacking somatic hypermutations are produced in the secondary response of C57BL/6 mice to (4-hydroxy-3-nitrophenyl)acetyl hapten.Antibodies to myelin oligodendrocyte glycoprotein are not involved in the severity of chronic non-remitting experimental autoimmune encephalomyelitis.Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID.AID is required for germinal center-derived lymphomagenesis.Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus.Identification of a specific domain required for dimerization of activation-induced cytidine deaminaseIdentification of a specific domain required for dimerization of activation-induced cytidine deaminase. VOLUME 281 (2006) PAGES 19115-19123
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description
researcher ORCID ID = 0000-0002-0153-3533
@en
wetenschapper
@nl
name
Masamichi Muramatsu
@ast
Masamichi Muramatsu
@en
Masamichi Muramatsu
@es
Masamichi Muramatsu
@nl
type
label
Masamichi Muramatsu
@ast
Masamichi Muramatsu
@en
Masamichi Muramatsu
@es
Masamichi Muramatsu
@nl
prefLabel
Masamichi Muramatsu
@ast
Masamichi Muramatsu
@en
Masamichi Muramatsu
@es
Masamichi Muramatsu
@nl
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P31
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0000-0002-0153-3533