about
Identification of a consensus site for TRAF6/p62 polyubiquitinationCyclooxygenase-2 in epilepsy.Lead optimization studies of cinnamic amide EP2 antagonistsNeuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor.Development of second generation EP2 antagonists with high selectivitySmall molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2.SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity.Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticusCandidate drug targets for prevention or modification of epilepsyaPKC phosphorylation of HDAC6 results in increased deacetylation activityEP2 Receptor Signaling Regulates Microglia Death.Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation.EP2 receptor signaling pathways regulate classical activation of microglia.Posttranslational modifications and receptor-associated proteins in AMPA receptor trafficking and synaptic plasticity.Discovery and characterization of carbamothioylacrylamides as EP2 selective antagonists.Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to BedsideDefining the therapeutic time window for suppressing the inflammatory prostaglandin E2 signaling after status epilepticus.AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62.Cyclooxygenase-2 in glioblastoma multiforme.Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype.Behavioral effects of SQSTM1/p62 overexpression in mice: support for a mitochondrial role in depression and anxietySubarachnoid blood acutely induces spreading depolarizations and early cortical infarction.Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2.Prostaglandin E2 Signaling: Alternative Target for Glioblastoma?Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growthSuppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injuryAssessment of the in vitro toxicity of calixarenes and a metal-seamed calixarene: a chemical pathway for clinical applicationG protein-coupled receptors in acquired epilepsy: Druggability and translatabilityInverse Agonism of Cannabinoid Receptor Type 2 Confers Anti-inflammatory and Neuroprotective Effects Following Status Epileptics
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description
researcher ORCID ID = 0000-0003-3955-8928
@en
wetenschapper
@nl
name
Jianxiong Jiang
@ast
Jianxiong Jiang
@en
Jianxiong Jiang
@es
Jianxiong Jiang
@nl
type
label
Jianxiong Jiang
@ast
Jianxiong Jiang
@en
Jianxiong Jiang
@es
Jianxiong Jiang
@nl
prefLabel
Jianxiong Jiang
@ast
Jianxiong Jiang
@en
Jianxiong Jiang
@es
Jianxiong Jiang
@nl
P106
P1153
55676486500
57203628935
P31
P496
0000-0003-3955-8928