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Defining a new biomarker for the autoimmune component of Multiple Sclerosis: Th40 cells.CD40 glycoforms and TNF-receptors 1 and 2 in the formation of CD40 receptor(s) in autoimmunityA CD40-targeted peptide controls and reverses type 1 diabetes in NOD mice.Galectin-9 controls CD40 signaling through a Tim-3 independent mechanism and redirects the cytokine profile of pathogenic T cells in autoimmunity.Th40 cells (CD4+CD40+ Tcells) drive a more severe form of Experimental Autoimmune Encephalomyelitis than conventional CD4 T cells.High distribution of CD40 and TRAF2 in Th40 T cell rafts leads to preferential survival of this auto-aggressive population in autoimmunityCD40 interacts directly with RAG1 and RAG2 in autoaggressive T cells and Fas prevents CD40-induced RAG expression.HIV-1 Tat regulates the SOD2 basal promoter by altering Sp1/Sp3 binding activity.Modification of enzyme-conjugated streptavidin-biotin western blot technique to avoid detection of endogenous biotin-containing proteins.The human immunodeficiency virus-1 Tat protein increases cell proliferation, alters sensitivity to zinc chelator-induced apoptosis, and changes Sp1 DNA binding in HeLa cells.CD40-mediated signalling influences trafficking, T-cell receptor expression, and T-cell pathogenesis, in the NOD model of type 1 diabetes.Peripheral CD4loCD40+ auto-aggressive T cell expansion during insulin-dependent diabetes mellitus.Identification of the candidate ALS2 gene at chromosome 2q33 as a human aldehyde oxidase gene.A unique T cell subset described as CD4loCD40+ T cells (TCD40) in human type 1 diabetes.Molecular cloning, refined chromosomal mapping and structural analysis of the human gene encoding aldehyde oxidase (AOX1), a candidate for the ALS2 gene.CD40 engagement of CD4+ CD40+ T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts toleranceAre we aiming to miss in translational autoimmunity treatments?HIV-1 Tat increases endothelial solute permeability through tyrosine kinase and mitogen-activated protein kinase-dependent pathways
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description
researcher ORCID ID = 0000-0001-6413-8322
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wetenschapper
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name
Gisela M Vaitaitis
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Gisela M Vaitaitis
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Gisela M Vaitaitis
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label
Gisela M Vaitaitis
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Gisela M Vaitaitis
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Gisela M Vaitaitis
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Gisela M Vaitaitis
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Gisela M Vaitaitis
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Gisela M Vaitaitis
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P106
P31
P496
0000-0001-6413-8322