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Processing of microRNA primary transcripts requires heme in mammalian cellsDimerization and Heme Binding Are Conserved in Amphibian and Starfish Homologues of the microRNA Processing Protein DGCR8Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidaseDiGeorge critical region 8 (DGCR8) is a double-cysteine-ligated heme proteinPqqD is a novel peptide chaperone that forms a ternary complex with the radical S-adenosylmethionine protein PqqE in the pyrroloquinoline quinone biosynthetic pathway.Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing.Identification of a cis-acting element that localizes mRNA to synapsesCobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency.Primary microRNA processing assay reconstituted using recombinant Drosha and DGCR8.Demonstration That the Radical S-Adenosylmethionine (SAM) Enzyme PqqE Catalyzes de Novo Carbon-Carbon Cross-linking within a Peptide Substrate PqqA in the Presence of the Peptide Chaperone PqqDAt the confluence of ribosomally synthesized peptide modification and radical S-adenosylmethionine (SAM) enzymology.CO and NO bind to Fe(II) DiGeorge critical region 8 heme but do not restore primary microRNA processing activity.
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description
researcher ORCID ID = 0000-0003-1805-1415
@en
wetenschapper
@nl
name
Ian Barr
@ast
Ian Barr
@en
Ian Barr
@es
Ian Barr
@nl
type
label
Ian Barr
@ast
Ian Barr
@en
Ian Barr
@es
Ian Barr
@nl
prefLabel
Ian Barr
@ast
Ian Barr
@en
Ian Barr
@es
Ian Barr
@nl
P106
P31
P496
0000-0003-1805-1415