about
PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activityA new family of receptor tyrosine kinases with a venus flytrap binding domain in insects and other invertebrates activated by aminoacids.Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation?GABAB receptor upregulates fragile X mental retardation protein expression in neuronsAllosteric functioning of dimeric class C G-protein-coupled receptors.Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning.Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia.PROK2/PROKR2 Signaling and Kallmann Syndrome.Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptorsComplex GABAB receptor complexes: how to generate multiple functionally distinct units from a single receptor.G-protein-coupled receptor oligomers: two or more for what? Lessons from mGlu and GABAB receptors.Dimers and beyond: The functional puzzles of class C GPCRs.Dynamics and modulation of metabotropic glutamate receptors.Mutational analysis of an antigenic peptide shows recognition in a loop conformation.Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer.Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells.A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors.Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement.Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons.Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit.Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.A comparative phenotypic study of kallmann syndrome patients carrying monoallelic and biallelic mutations in the prokineticin 2 or prokineticin receptor 2 genes.Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption.FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABAB Receptor.Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics.Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacyA mutational approach shows similar mechanisms of recognition for the isolated and integrated versions of a protein epitopeCoupling of agonist binding to effector domain activation in metabotropic glutamate-like receptorsBiased signaling through G-protein-coupled PROKR2 receptors harboring missense mutationsRearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomerStructural basis of the activation of a metabotropic GABA receptor
P50
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P50
description
researcher ORCID ID = 0000-0003-1134-2738
@en
wetenschapper
@nl
name
Philippe Rondard
@ast
Philippe Rondard
@en
Philippe Rondard
@es
Philippe Rondard
@nl
type
label
Philippe Rondard
@ast
Philippe Rondard
@en
Philippe Rondard
@es
Philippe Rondard
@nl
prefLabel
Philippe Rondard
@ast
Philippe Rondard
@en
Philippe Rondard
@es
Philippe Rondard
@nl
P106
P1153
7801595920
P31
P496
0000-0003-1134-2738