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The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activationRegulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC- cells and CD4(+)CD8(-) thymocytesExogenous amino acids are essential for interleukin-7 induced CD8 T cell growth. [corrected]Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels.Evidence of STAT5-dependent and -independent routes to CD8 memory formation and a preferential role for IL-7 over IL-15 in STAT5 activationThe third function of the thymus.Homeostatic proliferation and IL-7R alpha expression do not correlate with enhanced T cell proliferation and protection in chronic mouse malariaTissue specific deletion of inhibitor of kappa B kinase 2 with OX40-Cre reveals the unanticipated expression from the OX40 locus in skin epidermis.Zap70 is essential for long-term survival of naive CD8 T cellsSpatial heterogeneity and peptide availability determine CTL killing efficiency in vivo.Interleukin-7 influences FOXP3+CD4+ regulatory T cells peripheral homeostasis.The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development.Regulation of peripheral T-cell homeostasis by receptor signalling.Sensory adaptation in naive peripheral CD4 T cells.Temporal fate mapping reveals age-linked heterogeneity in naive T lymphocytes in mice.Differential requirement for IL-2 and IL-15 during bifurcated development of thymic regulatory T cellsTNF activation of NF-κB is essential for development of single-positive thymocytesNF-κB signaling mediates homeostatic maturation of new T cells.The role of the thymus in the control of autoimmunity.Thymic IL-7 signaling goes beyond survival.Role of CD4+CD8- thymocytes in the prevention of autoimmune diabetes.A Zap70-dependent feedback circuit is essential for efficient selection of CD4 lineage thymocytes.Homeostatic mechanisms in the control of autoimmunity.IL-7 determines the homeostatic fitness of T cells by distinct mechanisms at different signalling thresholds in vivo.TCR signals mediated by Src family kinases are essential for the survival of naive T cells.TCR and IL-7 receptor signals can operate independently or synergize to promote lymphopenia-induced expansion of naive T cells.Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells.Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation.Fyn regulates the duration of TCR engagement needed for commitment to effector function.Age is not just a number: Naive T cells increase their ability to persist in the circulation over time.IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes.Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κBInducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP ThymocytesCD4+CD8- thymocytes that express L-selectin protect rats from diabetes upon adoptive transferDeaggregated homologous immunoglobulin-peptide conjugates induce peptide-specific T cell nonresponsiveness in vivoEmpowering T helper 17 cells in autoimmunityDifferential impact of self and environmental antigens on the ontogeny and maintenance of CD4 T cell memoryThe natural history of naive T cells from birth to maturityFlip the coin: IL-7 and IL-7R in health and disease
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description
researcher ORCID ID = 0000-0003-4352-3373
@en
wetenschapper
@nl
name
Benedict Seddon
@ast
Benedict Seddon
@en
Benedict Seddon
@es
Benedict Seddon
@nl
type
label
Benedict Seddon
@ast
Benedict Seddon
@en
Benedict Seddon
@es
Benedict Seddon
@nl
prefLabel
Benedict Seddon
@ast
Benedict Seddon
@en
Benedict Seddon
@es
Benedict Seddon
@nl
P21
P31
P496
0000-0003-4352-3373