TCR signals mediated by Src family kinases are essential for the survival of naive T cells.
about
The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activationT cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in miceMicrotubule and Actin Interplay Drive Intracellular c-Src TraffickingPeptide length determines the outcome of TCR/peptide-MHCI engagementSrc-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survivalImpact of the TCR signal on regulatory T cell homeostasis, function, and traffickingThe interaction of LCK and the CD4 co-receptor alters the dose response of T-cells to interleukin-7.Redirecting the immune response: role of adoptive T cell therapy.Control of homeostatic proliferation by regulatory T cells.The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and functionZap70 is essential for long-term survival of naive CD8 T cellsThe importance of LAT in the activation, homeostasis, and regulatory function of T cellsLoss of tonic T-cell receptor signals alters the generation but not the persistence of CD8+ memory T cellsT-cell growth, cell surface organization, and the galectin-glycoprotein lattice.The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens.Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses.Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response.The Ebola Interferon Inhibiting Domains Attenuate and Dysregulate Cell-Mediated Immune Responses.Temporal fate mapping reveals age-linked heterogeneity in naive T lymphocytes in mice.Fluctuating fitness shapes the clone-size distribution of immune repertoires.Clonally diverse T cell homeostasis is maintained by a common program of cell-cycle control.B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency.Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune systemRegulation of T cell-dendritic cell interactions by IL-7 governs T-cell activation and homeostasis.Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells.A mechanistic model for naive CD4 T cell homeostasis in healthy adults and children.Lymphocytosis after treatment with dasatinib in chronic myeloid leukemia: Effects on response and toxicitySignalling crosstalk in B cells: managing worth and need.Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection.NF-κB signaling mediates homeostatic maturation of new T cells.Update on lymphocyte specific kinase inhibitors: a patent survey.CD8 T cell quiescence revisited.Regulating naïve and memory CD8 T cell homeostasis--a role for protein tyrosine phosphatases.Innate memory T cells.Individual MHCI-Restricted T-Cell Receptors are Characterized by a Unique Peptide Recognition Signature.Lck regulates IL-10 expression in memory-like Th1 cells.Initiation of TCR phosphorylation and signal transduction.IL-7 determines the homeostatic fitness of T cells by distinct mechanisms at different signalling thresholds in vivo.Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells.The Epstein-Barr virus protein, latent membrane protein 2A, co-opts tyrosine kinases used by the T cell receptor.
P2860
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P2860
TCR signals mediated by Src family kinases are essential for the survival of naive T cells.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
TCR signals mediated by Src fa ...... the survival of naive T cells.
@en
TCR signals mediated by Src fa ...... the survival of naive T cells.
@nl
type
label
TCR signals mediated by Src fa ...... the survival of naive T cells.
@en
TCR signals mediated by Src fa ...... the survival of naive T cells.
@nl
prefLabel
TCR signals mediated by Src fa ...... the survival of naive T cells.
@en
TCR signals mediated by Src fa ...... the survival of naive T cells.
@nl
P1476
TCR signals mediated by Src fa ...... the survival of naive T cells.
@en
P304
P356
10.4049/JIMMUNOL.169.6.2997
P407
P577
2002-09-01T00:00:00Z