about
Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses.Tumor cell death induced by topoisomerase-targeting drugs.Acidic pH induces topoisomerase II-mediated DNA damage.Evaluation of an Epitypified Ophiocordyceps formosana (Cordyceps s.l.) for Its Pharmacological PotentialDocosahexaenoic acid enhances hepatic serum amyloid A expression via protein kinase A-dependent mechanism.Single-stranded DNA induces ataxia telangiectasia mutant (ATM)/p53-dependent DNA damage and apoptotic signals.Rhapontigenin inhibits TGF-β-mediated epithelial‑mesenchymal transition via the PI3K/AKT/mTOR pathway and is not associated with HIF-1α degradation.Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers.A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I.DNA topoisomerase III alpha regulates p53-mediated tumor suppression.A negative feedback of the HIF-1α pathway via interferon-stimulated gene 15 and ISGylation.Cell type-specific effects of Adenosine 5'-triphosphate and pyrophosphate on the antitumor activity of doxorubicin.Docosahexaenoic acid suppresses the expression of FoxO and its target genes.Mitoxantrone inhibits HIF-1α expression in a topoisomerase II-independent pathway.Calcium-induced cleavage of DNA topoisomerase I involves the cytoplasmic-nuclear shuttling of calpain 2.WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers.Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult.Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity.Hydrogen peroxide induces topoisomerase I-mediated DNA damage and cell death.5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity.Substituted dibenzo[c,h]cinnolines: topoisomerase I-targeting anticancer agents.DNA damage-mediated apoptosis induced by selenium compounds.Inactivation of Cdc13p triggers MEC1-dependent apoptotic signals in yeast.Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.Aminoglycoside complexation with a DNA.RNA hybrid duplex: the thermodynamics of recognition and inhibition of RNA processing enzymes.Multiple domains of the tobacco mosaic virus p126 protein can independently suppress local and systemic RNA silencing.Cellular processing pathways contribute to the activation of etoposide-induced DNA damage responses.Involvement of p38 MAPK in the Anticancer Activity of Cultivated Cordyceps militaris.Differential Poisoning of Topoisomerases by Menogaril and Nogalamycin Dictated by the Minor Groove-Binding Nogalose Sugar†Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugates.DNA minor groove binding-directed poisoning of human DNA topoisomerase I by terbenzimidazolesDiaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profilesSynergistic property of cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cells
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P50
description
Forscher
@de
chercheur
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investigador
@es
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
研究者
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name
Tsai-Kun Li
@ast
Tsai-Kun Li
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Tsai-Kun Li
@es
Tsai-Kun Li
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type
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Tsai-Kun Li
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Tsai-Kun Li
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Tsai-Kun Li
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Tsai-Kun Li
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prefLabel
Tsai-Kun Li
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Tsai-Kun Li
@en
Tsai-Kun Li
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Tsai-Kun Li
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P108
P1153
7406375288
P31
P496
0000-0003-0393-2340