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PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the NLRP3 Inflammasome.GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans.Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in miceA small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.Small-Molecule Inhibitors of the SOX18 Transcription Factor.Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice.The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals.Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibitionT helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice.Natural product and natural product derived drugs in clinical trials.Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors.Human Monocytes Engage an Alternative Inflammasome Pathway.Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.Inflammasomes in the lung.Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress.Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli.Efficient synthesis of anacardic acid analogues and their antibacterial activities.NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.Antimicrobial octapeptin C4 analogues active against Cryptococcus species.The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype.An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes.Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950.Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950.Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis.An optimized whole blood assay measuring expression and activity of NLRP3-, NLRC4 and AIM2-inflammasomes.The Bohlmann–Rahtz route to functionalised pyridine scaffolds and their use in library synthesisInflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in miceCharacterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signallingA multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasomeHigh-performance liquid chromatographic separation of natural and synthetic desulphoglucosinolates and their chemical validation by UV, NMR and chemical ionisation-MS methodsBacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasomeCaspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degenerationInflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the LungMCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
P50
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researcher ORCID ID = 0000-0002-9652-8357
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Avril A.B. Robertson
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Avril A.B. Robertson
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Avril A.B. Robertson
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Avril A.B. Robertson
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