about
Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutationDiscovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.Design, Synthesis, and Initial Evaluation of Affinity-Based Small-Molecule Probes for Fluorescent Visualization and Specific Detection of Keap1.Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions.Molecular similarity guided optimization of novel Nrf2 activators with 1,2,4-oxadiazole core.The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update.Structure-Activity and Structure-Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor.Polar Recognition Group Study of Keap1-Nrf2 Protein-Protein Interaction InhibitorsDiscovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency.Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis.Development of Novel Nrf2/ARE Inducers Bearing Pyrazino[2,1-a]isoquinolin Scaffold with Potent In Vitro Efficacy and Enhanced Physicochemical Properties.Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway.Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation.Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein KnockdownCorrigendum to "3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1, 2, 4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation"Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancerStructure-activity and structure-property relationships of novel Nrf2 activators with a 1,2,4-oxadiazole core and their therapeutic effects on acetaminophen (APAP)-induced acute liver injuryDiscovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced HepatotoxRecent progress in the development of small molecule Nrf2 activators: a patent review (2017-present)Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interactionNuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer Therapy
P50
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P50
description
researcher ORCID ID = 0000-0002-1671-1582
@en
name
Zhengyu Jiang
@ast
Zhengyu Jiang
@en
Zhengyu Jiang
@es
Zhengyu Jiang
@nl
type
label
Zhengyu Jiang
@ast
Zhengyu Jiang
@en
Zhengyu Jiang
@es
Zhengyu Jiang
@nl
prefLabel
Zhengyu Jiang
@ast
Zhengyu Jiang
@en
Zhengyu Jiang
@es
Zhengyu Jiang
@nl
P31
P496
0000-0002-1671-1582