Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.
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Nrf2 and Notch Signaling in Lung Cancer: Near the CrossroadDiscovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agentsDrug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation SpectroscopyNew approaches to treating Alzheimer's diseaseState-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK PathwaySmall molecules, big targets: drug discovery faces the protein-protein interaction challenge.Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.Non-electrophilic modulators of the canonical Keap1/Nrf2 pathwayDiscovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's diseaseAn inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitisRole of the Nrf2 signaling system in health and disease.Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1.Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis.The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update.The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases.Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).A systematic molecular dynamics approach to the study of peptide Keap1-Nrf2 protein-protein interaction inhibitors and its application to p62 peptides.Multiple binding modes of a small molecule to human Keap1 revealed by X-ray crystallography and molecular dynamics simulation.Polar Recognition Group Study of Keap1-Nrf2 Protein-Protein Interaction InhibitorsReversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy.Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cellsCharacterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling.Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis.Development of Novel Nrf2/ARE Inducers Bearing Pyrazino[2,1-a]isoquinolin Scaffold with Potent In Vitro Efficacy and Enhanced Physicochemical Properties.Theoretical models of inhibitory activity for inhibitors of protein–protein interactions: targeting menin–mixed lineage leukemia with small molecules† †Electronic Supplementary Information (ESI) available: Detailed characterization of the compound cTheoretical models of inhibitory activity for inhibitors of protein-protein interactions: targeting menin-mixed lineage leukemia with small molecules.Identification of a novel small-molecule Keap1-Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy.Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a reviewThe mycosporine-like amino acids porphyra-334 and shinorine are antioxidants and direct antagonists of Keap1-Nrf2 binding
P2860
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P2860
Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.
description
2014 nî lūn-bûn
@nan
2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Discovery of potent Keap1-Nrf2 ...... binding determinants analysis.
@ast
Discovery of potent Keap1-Nrf2 ...... binding determinants analysis.
@en
type
label
Discovery of potent Keap1-Nrf2 ...... binding determinants analysis.
@ast
Discovery of potent Keap1-Nrf2 ...... binding determinants analysis.
@en
prefLabel
Discovery of potent Keap1-Nrf2 ...... binding determinants analysis.
@ast
Discovery of potent Keap1-Nrf2 ...... binding determinants analysis.
@en
P2093
P356
P1476
Discovery of potent Keap1-Nrf2 ...... binding determinants analysis.
@en
P2093
Mei-Yang Xi
Meng-Chen Lu
Qi-Dong You
Ting-Ting Yang
Xiao-Jin Zhang
Xiao-Ke Guo
Xiao-Li Xu
P304
P356
10.1021/JM5000529
P407
P577
2014-02-21T00:00:00Z