about
Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndromeRTEL1 (regulator of telomere elongation helicase 1), a DNA helicase essential for genome stabilityHuman POT1 is required for efficient telomere C-rich strand replication in the absence of WRN.Replication timing of human telomeres is chromosome arm-specific, influenced by subtelomeric structures and connected to nuclear localization.The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeresThe effect of TERC haploinsufficiency on the inheritance of telomere length.TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.The heterochromatic chromosome caps in great apes impact telomere metabolismTelomere length profiles in humans: all ends are not equal.Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination.Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin.Resistance to the short term antiproliferative activity of the G-quadruplex ligand 12459 is associated with telomerase overexpression and telomere capping alteration.Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line.The senescent microenvironment promotes the emergence of heterogeneous cancer stem-like cells.Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas.Clinical value of ERG, TFF3, and SPINK1 for molecular subtyping of prostate cancer.Human RTEL1 stabilizes long G-overhangs allowing telomerase-dependent over-extension.Telomere Length Analysis by Quantitative Fluorescent in Situ Hybridization (Q-FISH).CD24 expression and stem-associated features define tumor cell heterogeneity and tumorigenic capacities in a model of carcinogenesis
P50
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P50
name
Arturo Londoño-Vallejo
@ast
Arturo Londoño-Vallejo
@en
Arturo Londoño-Vallejo
@nl
type
label
Arturo Londoño-Vallejo
@ast
Arturo Londoño-Vallejo
@en
Arturo Londoño-Vallejo
@nl
prefLabel
Arturo Londoño-Vallejo
@ast
Arturo Londoño-Vallejo
@en
Arturo Londoño-Vallejo
@nl