about
Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctionsBacterial Exotoxins and the InflammasomeAnthrax lethal and edema toxins in anthrax pathogenesisAntidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chainDetection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticlesMonoclonal antibody therapies against anthraxAnthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasomeAnthrax lethal toxin activates the inflammasome in sensitive rat macrophagesCapillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo.Efficient neutralization of anthrax toxin by chimpanzee monoclonal antibodies against protective antigen.Role of N-terminal amino acids in the potency of anthrax lethal factor.The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS).Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1Auranofin protects against anthrax lethal toxin-induced activation of the Nlrp1b inflammasomeInflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment.Key tissue targets responsible for anthrax-toxin-induced lethality.Endocrine perturbation increases susceptibility of mice to anthrax lethal toxin.Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design.Phase 1 study of a recombinant mutant protective antigen of Bacillus anthracis.Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challengeAntidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy.Anthrax lethal toxin induces ketotifen-sensitive intradermal vascular leakage in certain inbred miceAnthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages.MyD88-dependent signaling protects against anthrax lethal toxin-induced impairment of intestinal barrier function.Quickening the pace of anthrax research: three advances point towards possible therapies.Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice.Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumorsTranscriptional analysis of the three Nlrp1 paralogs in mice.Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy.Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model.Oxidized ATP protection against anthrax lethal toxin.Cisplatin inhibition of anthrax lethal toxin.Anthrax edema factor toxicity is strongly mediated by the N-end ruleAnthrax lethal factor represses glucocorticoid and progesterone receptor activity.Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in miceInflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii.The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomesA heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model.A Bacillus anthracis strain deleted for six proteases serves as an effective host for production of recombinant proteinsLipoprotein biosynthesis by prolipoprotein diacylglyceryl transferase is required for efficient spore germination and full virulence of Bacillus anthracis.
P50
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P50
description
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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Mahtab Moayeri
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1968-06-26T00:00:00Z
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