about
Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracilEmbryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stabilityRett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressorMeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain.Correction of liver dysfunction in DNA repair-deficient mice with an ERCC1 transgene.Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome.Stability of HPRT marker gene expression at different gene-targeted loci: observing and overcoming a position effect.Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout miceA dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.The molecular basis of variable phenotypic severity among common missense mutations causing Rett syndromeCpG islands influence chromatin structure via the CpG-binding protein Cfp1.The role of MeCP2 in the brain.A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog.Kaiso-deficient mice show resistance to intestinal cancer.Radically truncated MeCP2 rescues Rett syndrome-like neurological defects.Exclusive expression of MeCP2 in the nervous system distinguishes between brain and peripheral Rett syndrome-like phenotypes.53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin.A mutation-led search for novel functional domains in MeCP2.A mutation-led search for novel functional domains in MeCP2Affinity for DNA Contributes to NLS Independent Nuclear Localization of MeCP2Toxicity of overexpressed MeCP2 is independent of HDAC3 activityDomains of methylated CAC and CG target MeCP2 to tune transcription in the brainA position- and orientation-dependent element in the first intron is required for expression of the mouse hprt gene in embryonic stem cellsA one-step gene amplification system for use in cultured mammalian cells and transgenic animalsMice with DNA repair gene Ercc1 deficiency in a neural crest lineage are a model for late-onset Hirschsprung disease
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Jim Selfridge
@ast
Jim Selfridge
@en
Jim Selfridge
@es
Jim Selfridge
@nl
type
label
Jim Selfridge
@ast
Jim Selfridge
@en
Jim Selfridge
@es
Jim Selfridge
@nl
prefLabel
Jim Selfridge
@ast
Jim Selfridge
@en
Jim Selfridge
@es
Jim Selfridge
@nl
P106
P31
P496
0000-0003-2473-4386