Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability - Wikidata - wikimedia - TriplyDB

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

http://www.wikidata.org/entity/Q28508931

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Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA Repair of oxidative DNA damage and cancer: recent progress in DNA base excision repair Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation Active DNA demethylation in post-mitotic neurons: a reason for optimism Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers DNA glycosylases: in DNA repair and beyond DNA methylation in mammals The roles of retinoic acid and retinoic acid receptors in inducing epigenetic changes Mechanism and function of oxidative reversal of DNA and RNA methylation DNA demethylation and invasive cancer: implications for therapeutics The role of DNA methylation in aging, rejuvenation, and age-related disease Base excision repair and cancer Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues Chromatin remodelling complex RSC promotes base excision repair in chromatin of Saccharomyces cerevisiae.DNA methylation, its mediators and genome integrity Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles Base excision repair Processive DNA demethylation via DNA deaminase-induced lesion resolution Pleiotropy as the Mechanism for Evolving Novelty: Same Signal, Different Result Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome Dependence of substrate binding and catalysis on pH, ionic strength, and temperature for thymine DNA glycosylase: Insights into recognition and processing of G·T mispairs A TDG/CBP/RARα ternary complex mediates the retinoic acid-dependent expression of DNA methylation-sensitive genes CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase CGGBP1 mitigates cytosine methylation at repetitive DNA sequences.Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA Dynamics of 5-carboxylcytosine during hepatic differentiation: Potential general role for active demethylation by DNA repair in lineage specification.Base excision repair of tandem modifications in a methylated CpG dinucleotide.Active demethylation in mouse zygotes involves cytosine deamination and base excision repair TET enzymes, TDG and the dynamics of DNA demethylation.Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells.Histone/protein deacetylase SIRT1 is an anticancer therapeutic target.5-Formylcytosine can be a stable DNA modification in mammals.No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice

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Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

http://www.wikidata.org/entity/Q28508931

description

2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

article publié dans la revue scientifique Nature

@fr

artículu científicu espublizáu en 2011

@ast

scientific journal article

@en

vedecký článok (publikovaný 2011/02/17)

@sk

vědecký článek publikovaný v roce 2011

@cs

wetenschappelijk artikel (gepubliceerd op 2011/02/17)

@nl

наукова стаття, опублікована в лютому 2011

@uk

مقالة علمية (نشرت في 17-2-2011)

@ar

name

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

@ast

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

@en

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

@nl

type

label

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

@ast

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

@en

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

@nl

prefLabel

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

@ast

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

@en

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

@nl

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Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

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Angelika L. Jacobs

http://www.w3.org/2001/XMLSchema#string

Annika Wirz

http://www.w3.org/2001/XMLSchema#string

Daniel Cortázar

http://www.w3.org/2001/XMLSchema#string

David Schuermann

http://www.w3.org/2001/XMLSchema#string

Eilidh MacDougall

http://www.w3.org/2001/XMLSchema#string

Fredy Siegrist

http://www.w3.org/2001/XMLSchema#string

Josef Jiricny

http://www.w3.org/2001/XMLSchema#string

Roland Steinacher

http://www.w3.org/2001/XMLSchema#string

Teresa Lettieri

http://www.w3.org/2001/XMLSchema#string

Yusuke Saito

http://www.w3.org/2001/XMLSchema#string

P2860

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha

Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription

Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming

A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Polycomb complexes repress developmental regulators in murine embryonic stem cells

Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

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419–423

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scholarly article

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400395

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10.1038/NATURE09672

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7334

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470

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Adrian Peter Bird

Christophe Kunz

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2011-02-17T00:00:00Z

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49796055

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1036300730

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21278727

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Thymine DNA glycosylase