about
ERbeta Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminusMicroglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke.Two resistance to thyroid hormone mutants with impaired hormone bindingLeukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapyEliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.Inhibition of CSF-1R supports T-cell mediated melanoma therapyA method for isolation of intact, translationally active ribonucleic acid.Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain.Selective modulation of thyroid hormone receptor action.CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus.CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy.Characterizing newly repopulated microglia in the adult mouse: impacts on animal behavior, cell morphology, and neuroinflammation.Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice.Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity.Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responsesOrally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study.Interaction of a tissue-specific factor with an essential rat growth hormone gene promoter element.Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization.Colony-Stimulating Factor 1 Receptor Antagonists Sensitize Human Immunodeficiency Virus Type 1-Infected Macrophages to TRAIL-Mediated Killing.Elimination of microglia improves cognitive function following cranial irradiationCreatine kinase protein sequence encoded by a cDNA made from Torpedo californica electric organ mRNA.Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates.Dynamic microglial modulation of spatial learning and social behavior.Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in mice.The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators.Eukaryotic regulatory elements lurking in plasmid DNA: the activator protein-1 site in pUC.Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist.Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas.Identification of the putative MAP kinase docking site in the thyroid hormone receptor-beta1 DNA-binding domain: functional consequences of mutations at the docking site.Resolution by diagonal gel mobility shift assays of multisubunit complexes binding to a functionally important element of the rat growth hormone gene promoter.Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression.Microglial repopulation resolves inflammation and promotes brain recovery after injury.The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs).Molecular and structural biology of thyroid hormone receptors.Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies.Expression of the rat alpha 1 thyroid hormone receptor ligand binding domain in Escherichia coli and the use of a ligand-induced conformation change as a method for its purification to homogeneity.A structural role for hormone in the thyroid hormone receptor.Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain.Macrophage Depletion Ameliorates Peripheral Neuropathy in Aging Mice.
P50
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P50
description
Forscher
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chercheur
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investigador
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researcher
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ricercatore
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wetenschapper
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研究者
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name
B L West
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B L West
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Brian West
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Brian West
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B L West
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B L West
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Brian West
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Brian West
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B L West
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B L West
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B L West
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Brian West
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Brian West
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P31
P496
0000-0002-5320-3691