about
Aspirin inhibits camptothecin-induced p21CIP1 levels and potentiates apoptosis in human breast cancer cellsA conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma CareHuman Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNAEnzymic conversion of agmatine to putrescine in Lathyrus sativus seedlings. Purification and properties of a multifunctional enzyme (putrescine synthase)RNF2 is the target for phosphorylation by the p38 MAPK and ERK signaling pathways.Modulation of gastrointestinal permeability of low-molecular-weight heparin by L-arginine: in-vivo and in-vitro evaluation.Targeting MDM2-p53 interaction for cancer therapy: are we there yet?Oral delivery of low-molecular-weight heparin using sodium caprate as absorption enhancer reaches therapeutic levelsMGMT inhibition restores ERα functional sensitivity to antiestrogen therapyDegradation of NF-κB, p53 and other regulatory redox-sensitive proteins by thiol-conjugating and -nitrosylating drugs in human tumor cells.Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress.The MDM2-p53 pathway revisitedDisulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage.Chemopreventative strategies targeting the MGMT repair protein: augmented expression in human lymphocytes and tumor cells by ethanolic and aqueous extracts of several Indian medicinal plants.S-thiolation mimicry: quantitative and kinetic analysis of redox status of protein cysteines by glutathione-affinity chromatography.DNA interstrand crosslinking and strand break repair in human glioma cell lines of varying [1,3-bis(2-chloroethyl)-1-nitrosourea] resistance.Blockade of MGMT expression by O6 benzyl guanine leads to inhibition of pancreatic cancer growth and induction of apoptosis.Conditional expression of type 2 angiotensin II receptor in rat vascular smooth muscle cells reveals the interplay of the angiotensin system in matrix metalloproteinase 2 expression and vascular remodeling.Decreased glucose transporter 1 gene expression and glucose uptake in fetal brain exposed to ethanol.The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein.Phosphorylation of O6-alkylguanine-DNA alkyltransferase: experience with a GST-fusion protein and a new pull-down assay.Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells.The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.Effects of ethanol ingestion on glucose transporter-1 protein and mRNA levels in rat brain.Differential removal of insulin-like growth factor binding proteins in rat serum by solvent extraction procedures.Alterations in the activities of DNA topoisomerase enzymes and O6-methylguanine-DNA-methyltransferase in septic rat liverDifferential modulation by spermidine of reactions catalyzed by type 1 prokaryotic and eukaryotic topoisomerasesModulation of the relaxing activity of Escherichia coli topoisomerase I by single-stranded DNA binding proteinsEscherichia coli DNA topoisomerase III: purification and characterization of a new type I enzymeAltered levels of mRNA encoding enzymes of hepatic glucose metabolism in septic ratsCoexistence of two pathways of spermidine biosynthesis in Lathyrus sativus seedlingsInsulin-like growth factors (IGF-I and IGF-II), IGF-binding proteins, and IGF gene expression in the offspring of ethanol-fed ratsActivity and distribution of the cysteine prodrug activating enzyme, 5-oxo-L-prolinase, in human normal and tumor tissuesNuclear magnetic resonance studies of polyamine binding to a defined DNA sequence
P50
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P50
description
Forscher
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研究者
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K S Srivenugopal
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K S Srivenugopal
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K S Srivenugopal
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K S Srivenugopal
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K S Srivenugopal
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K S Srivenugopal
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K S Srivenugopal
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K S Srivenugopal
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K S Srivenugopal
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K S Srivenugopal
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K S Srivenugopal
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K S Srivenugopal
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P31
P496
0000-0001-9837-3435