about
Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylationSelective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative diseaseBAFF, APRIL and human B cell disordersHuman TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndromeDominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiencyIL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells.Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and functionDivide and conquer: the importance of cell division in regulating B-cell responses.Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses.Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus.Functional STAT3 deficiency compromises the generation of human T follicular helper cells.Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs.Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.Follicular B helper T cells in antibody responses and autoimmunity.Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.Signal transducer and activator of transcription 3 limits Epstein-Barr virus lytic activation in B lymphocytes.A recurrent dominant negative E47 mutation causes agammaglobulinemia and BCR(-) B cells.Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficienciesNaive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells.Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiencyMemory B cells: effectors of long-lived immune responses.Primary immune deficiencies affecting lymphocyte differentiation: lessons from the spectrum of resulting infections.Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage.Regulation of T follicular helper cell formation and function by antigen presenting cells.SLAM family receptors and SAP adaptors in immunity.Staying alive: regulation of plasma cell survival.STAT3 is a central regulator of lymphocyte differentiation and function.XLP: clinical features and molecular etiology due to mutations in SH2D1A encoding SAP.Advances in IL-21 biology - enhancing our understanding of human disease.Human immunity against EBV-lessons from the clinic.Memory B cells: total recall.Genetic cause of immune dysregulation - one gene or two?IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice.Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies.
P50
Q24290951-3499C331-A744-4D2E-962B-1CEACC91C3ACQ24536218-CD5976F8-77F1-4AF1-8C11-BD1B60C34B42Q28258436-7FA81BD9-CDA2-42C5-9E9E-9E965F46A7D1Q28266613-747F5704-CA6A-494D-9BB0-02B5BCE19790Q34380652-4FFF31F5-6FDA-416C-8238-BB2086E3F2B8Q34420821-E8D5D2F9-2D95-470D-BA7C-3E2357491844Q34597428-BE5BB744-7262-45E6-862A-CF309BDFBA53Q35671239-B6ED7CEA-F3C2-470A-B44E-155B403B072CQ35843780-0E68A001-FC3A-427D-BC04-E26595AE460EQ35941417-3C681E26-7845-4280-81DB-2135E3D849FEQ35946132-B6047EB4-8950-4FFC-A9AC-D889A9927595Q35970620-29D5592E-ED57-45EC-84FC-50E0DF410B99Q36107766-DA7BE8BD-369E-44B3-B995-60CBD7862F33Q36206343-B111E700-0AD0-46BF-9E3A-B6830F2D72D4Q36219326-AD388CF6-9360-4571-9D91-4DD6431DF0F4Q36302329-447C7083-BF2C-4367-A633-E0B7CF8F51DAQ36742247-39F7CEF4-72FF-458B-AC55-DFCAE0DB5BB1Q37178987-2C34004B-1938-4377-9E29-D5E284E69A66Q37202661-494BDFD9-FA54-4B3B-A6E5-2D2F710A094CQ37252690-D396F81D-FB7A-41A2-B9B8-CBC402BCBCD9Q37259320-088AAE86-E389-46B5-A7F6-BC9CDB8EC671Q37296295-20D0544A-D50C-4BDE-8E29-39B640086580Q37322185-574FCD97-3123-4C53-B333-555634DD9142Q37346692-65C885EF-70F2-4966-B891-74AA6D8FDEA4Q37370670-2FF49D01-EB92-4502-8B4A-6A5A3A3227C6Q37549738-E56925FE-5785-47A1-9078-90F7CDCFB515Q37564257-91938106-4AC6-4432-A158-5D397175C916Q37571071-30ABEABB-9266-4AA3-94D0-8E67DEEE2ECCQ37589643-EDEE30A1-6F9E-4B05-881D-96F603B51457Q37813253-8CCE58CF-0230-421E-B683-13C235F594C6Q37827141-BEF58EBC-1152-449D-A04C-6D9F9D0959FEQ37946101-3E8702E8-7F1C-4A6D-B33D-9B667030C23DQ38193278-1BF56682-17A0-4699-9361-E58579FE1199Q38236177-C7D2ED66-2736-4284-9458-61C773CC58FDQ38388319-EE06723E-D36D-4E9F-B746-263B0178955FQ39097082-97D5043E-AECF-4568-A7DF-E48259D4EB2DQ39211347-BF5519B6-C7F0-4336-AE5C-3E624B193472Q39270981-343582C6-232B-4E0B-92BC-359EC702F4ADQ39399282-2E5C87ED-262A-4BC4-97D6-0B69269CD990Q40065888-3438390C-9A30-480F-A8B0-57E6386CC82E
P50
description
researcher
@en
wetenschapper
@nl
name
S G Tangye
@en
S G Tangye
@nl
type
label
S G Tangye
@en
S G Tangye
@nl
prefLabel
S G Tangye
@en
S G Tangye
@nl
P106
P31
P496
0000-0002-5360-5180