about
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's diseaseSynthesis of new (benzimidazolyl)piperazines with affinity for the 5-HT1A receptor via Pd(0) amination of bromobenzimidazoles.Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors.A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells.Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.Development of Fluorescent Ligands for the Human 5-HT1A Receptor.Development of molecular probes for the human 5-HT(6) receptor.A new serotonin 5-HT6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding.New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.New benzimidazole derivatives: selective and orally active 5-HT3 receptor antagonists.Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo.A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.Novel Inhibitors of Fatty Acid Synthase with Anticancer ActivityBenzimidazole derivatives. Part 1: Synthesis and structure–activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT4 receptor antagonistsBenzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptorsSynthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparisFirst pharmacophoric hypothesis for 5-HT7 antagonismComparative receptor mapping of serotoninergic 5-HT3 and 5-HT4 binding sites
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description
researcher
@en
wetenschapper
@nl
name
Bellinda Benhamú
@en
Benhamú B
@nl
type
label
Bellinda Benhamú
@en
Benhamú B
@nl
altLabel
Benhamú B
@en
prefLabel
Bellinda Benhamú
@en
Benhamú B
@nl
P106
P31
P496
0000-0002-0864-026X