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Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenesStructure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycinInsights into the bioactivity of mensacarcin and epoxide formation by MsnO8Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity.The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose.Novel avilamycin derivatives with improved polarity generated by targeted gene disruption.A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin.Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136.On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2).Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinCloning and heterologous expression of three type II PKS gene clusters from Streptomyces bottropensis.Development of intergeneric conjugal gene transfer system in Streptomyces diastatochromogenes 1628 and its application for improvement of toyocamycin production.Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes.A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene.Overexpression of ribosome recycling factor is responsible for improvement of nucleotide antibiotic-toyocamycin in Streptomyces diastatochromogenes 1628.Complete genome sequence of Saccharothrix espanaensis DSM 44229(T) and comparison to the other completely sequenced Pseudonocardiaceae.Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA-Specified Leu-tRNA(UUA) Molecule.A transposon-based strategy to identify the regulatory gene network responsible for landomycin E biosynthesis.Genes and enzymes involved in bacterial isoprenoid biosynthesis.Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of PseudonocardiaceaeSimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursorsNovel natural compounds obtained by genome-based screening and genetic engineering.Exploiting Pseudomonas putida for drug development.Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides.Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.The future of natural products as a source of new antibiotics.Tracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis.Glycosyltransferases, important tools for drug design.Features and applications of bacterial glycosyltransferases: current state and prospects.A bacterial glycosyltransferase gene toolbox: generation and applications.Combinatorial and synthetic biosynthesis in actinomycetes.The active conformation of avilamycin A is conferred by AviX12, a radical AdoMet enzyme.The Gene bldA, a regulator of morphological differentiation and antibiotic production in streptomyces.Aranciamycin analogs generated by combinatorial biosynthesis show improved antitumor activity.Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase.Bacillus cereus efflux protein BC3310 - a multidrug transporter of the unknown major facilitator family, UMF-2.Generation of novel landomycins M and O through targeted gene disruption.Genes involved in formation and attachment of a two-carbon chain as a component of eurekanate, a branched-chain sugar moiety of avilamycin A.Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2
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P50
name
Andreas Bechthold
@en
Andreas Bechthold
@nl
type
label
Andreas Bechthold
@en
Andreas Bechthold
@nl
prefLabel
Andreas Bechthold
@en
Andreas Bechthold
@nl