about
Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptorLaminin regulates PDGFRβ(+) cell stemness and muscle development.The GluK4 kainate receptor subunit regulates memory, mood, and excitotoxic neurodegeneration.Laminin is required for Schwann cell morphogenesisFibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's diseaseMesenchymal stem cells facilitate axon sorting, myelination, and functional recovery in paralyzed mice deficient in Schwann cell-derived laminin.A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease miceFibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis.Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brainAlzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization.Dissociation of mRNA cytoplasmic polyadenylation from translational activation by structural modification of the 5'-UTRTissue plasminogen activator is required for the development of fetal alcohol syndrome in mice.The cellular origin of laminin determines its role in blood pressure regulationActivation of the factor XII-driven contact system in Alzheimer's disease patient and mouse model plasma.Chronic Hypertension Leads to Neurodegeneration in the TgSwDI Mouse Model of Alzheimer's DiseaseAβ delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrin.The plasminogen activator system modulates sympathetic nerve function.Laminin gamma1 is critical for Schwann cell differentiation, axon myelination, and regeneration in the peripheral nerveThe Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII.Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke.Tissue plasminogen activator modulates the cellular and behavioral response to cocaine.Hyperhomocysteinemia exacerbates Alzheimer's disease pathology by way of the β-amyloid fibrinogen interactionRegulation of Schwann cell function by the extracellular matrix.A possible new role for Aβ in vascular and inflammatory dysfunction in Alzheimer's disease.Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity.Interactions of β-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's diseaseBiochemical and structural analysis of the interaction between β-amyloid and fibrinogen.Membrane depolarization induces calcium-dependent secretion of tissue plasminogen activator.Both laminin and Schwann cell dystroglycan are necessary for proper clustering of sodium channels at nodes of Ranvier.Fibrin deposited in the Alzheimer's disease brain promotes neuronal degenerationCortical deficiency of laminin gamma1 impairs the AKT/GSK-3beta signaling pathway and leads to defects in neurite outgrowth and neuronal migration.Disruption of laminin in the peripheral nervous system impedes nonmyelinating Schwann cell development and impairs nociceptive sensory function.Involvement of tissue plasminogen activator in stress responsivity during acute cocaine withdrawal in mice.Localization and regulation of the tissue plasminogen activator-plasmin system in the hippocampus.Tissue plasminogen activator in the bed nucleus of stria terminalis regulates acoustic startle.Fibrinogen in the Nervous System: Glia Beware.The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration.Stress-induced spine loss in the medial amygdala is mediated by tissue-plasminogen activator.Aminopyrimidine Class Aggregation Inhibitor Effectively Blocks Aβ-Fibrinogen Interaction and Aβ-Induced Contact System Activation.Blood will out: vascular contributions to Alzheimer's disease.
P50
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P50
description
researcher
@en
wetenschapper
@nl
name
Sidney Strickland
@en
Sidney Strickland
@nl
type
label
Sidney Strickland
@en
Sidney Strickland
@nl
prefLabel
Sidney Strickland
@en
Sidney Strickland
@nl
P106
P31
P496
0000-0002-3072-9244