about
Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in micePodoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture.Discordance between changes in the gut microbiota and pathogenicity in a mouse model of spontaneous colitis.Mucin-type O-glycosylation is critical for vascular integrity.Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets.O-glycans direct selectin ligands to lipid rafts on leukocytes.Loss of Core 1-derived O-Glycans Decreases Breast Cancer Development in MiceDefective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in MiceLoss of intestinal O-glycans promotes spontaneous duodenal tumors.Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in miceLenalidomide inhibits lymphangiogenesis in preclinical models of mantle cell lymphomaPlatelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells.Loss of mucin-type O-glycans impairs the integrity of the glomerular filtration barrier in the mouse kidney.Plasma soluble podoplanin is a novel marker for the diagnosis of tumor occurrence and metastasis.Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein traffickingDisruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in MiceCore 1-derived mucin-type O-glycosylation protects against spontaneous gastritis and gastric cancerDclk1 in tuft cells promotes inflammation-driven epithelial restitution and mitigates chronic colitis
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description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Jianxin Fu
@en
Jianxin Fu
@nl
type
label
Jianxin Fu
@en
Jianxin Fu
@nl
prefLabel
Jianxin Fu
@en
Jianxin Fu
@nl
P31
P496
0000-0002-3067-8539