about
Nucleation-dependent tau filament formation: the importance of dimerization and an estimation of elementary rate constantsAffinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy.Pathways of tau fibrillization.Tau isoform composition influences rate and extent of filament formationEvaluating triggers and enhancers of tau fibrillization.Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathologyInhibition of tau polymerization with a cyanine dye in two distinct model systemsStructure-activity relationship of cyanine tau aggregation inhibitors.Antibody uptake into neurons occurs primarily via clathrin-dependent Fcγ receptor endocytosis and is a prerequisite for acute tau protein clearance.Harnessing the immune system for treatment and detection of tau pathology.Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.Triggers of full-length tau aggregation: a role for partially folded intermediates.Tau-targeting therapies for Alzheimer diseaseTau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacyStructural characterization of monoclonal antibodies targeting C-terminal Ser404 region of phosphorylated tau protein
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Q30481896-3D10CE76-79A8-4A11-9658-213B05939540Q30805841-93857EA5-C731-4FB4-BBB5-6DE92215B4B2Q35992129-E40B7C39-799B-498D-96B7-085DD2F9B645Q36017002-118D83D0-062E-43F6-99E0-B9FAF6C06D68Q36231837-2847E65A-0B86-46FC-895B-7CEC2A38B127Q37311364-7D98A492-FB00-48E8-9BE2-95CF12D81FA5Q37344041-F4DE1F8D-6BA2-4626-A99E-6C29CA8DA523Q37349368-67C32991-B963-49B9-A817-3B89E8FDFA6FQ37368709-F6AE0CBE-6C4F-4117-95FD-0D734F9E9979Q38194049-BEAA8D29-18AC-4171-8F5F-BC825BB1D833Q42077623-21F60AE9-74C3-4092-A5C9-E937C9D77ACDQ46431919-B31D6012-9D2C-44D0-9B61-C586EFE3DCE8Q57178723-24FDABCE-A6F4-4CC2-8163-F3000E0FE835Q64060361-AFFB5741-6143-4B7D-AFA5-A2E660F6CB9EQ91827815-1E62DE0F-8929-436B-8829-78551F247E8D
P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Erin E Congdon
@en
Erin E Congdon
@nl
type
label
Erin E Congdon
@en
Erin E Congdon
@nl
prefLabel
Erin E Congdon
@en
Erin E Congdon
@nl
P31
P496
0000-0001-8322-6176