Tau isoform composition influences rate and extent of filament formation
about
Roles of tau protein in health and disease.Specific profile of tau isoforms in argyrophylic grain disease.MAPT as a predisposing gene for sporadic amyotrophic lateral sclerosis in the Chinese Han populationLysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity.A novel MAPT mutation, G55R, in a frontotemporal dementia patient leads to altered Tau function.Profiling murine tau with 0N, 1N and 2N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus.Expression of 1N3R-Tau isoform inhibits cell proliferation by inducing S phase arrest in N2a cells.Tau assembly: the dominant role of PHF6 (VQIVYK) in microtubule binding region repeat R3.Regulation of human MAPT gene expression.A novel Alzheimer disease locus located near the gene encoding tau protein.MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies.Initiation of assembly of tau(273-284) and its ΔK280 mutant: an experimental and computational study.Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau.Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells.Lysosomal fusion dysfunction as a unifying hypothesis for Alzheimer's disease pathology.Brain pathology in myotonic dystrophy: when tauopathy meets spliceopathy and RNAopathy.Impaired intracellular trafficking defines early Parkinson's diseaseExtracellular Tau Paired Helical Filaments Differentially Affect Tau Pathogenic Mechanisms in Mitotic and Post-Mitotic Cells: Implications for Mechanisms of Tau Propagation in the Brain.A Polymorphic Antioxidant Response Element Links NRF2/sMAF Binding to Enhanced MAPT Expression and Reduced Risk of Parkinsonian DisordersTau mis-splicing in the pathogenesis of neurodegenerative disorders.Prion-like Spreading in Tauopathies.Propagation of Tau aggregates.Tau and neuron aging.Hyperphosphorylation-induced tau oligomersAnalysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition.Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders.What is the evidence that tau pathology spreads through prion-like propagation?Detection and Quantification Methods for Fibrillar Products of In Vitro Tau Aggregation Assays.
P2860
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P2860
Tau isoform composition influences rate and extent of filament formation
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Tau isoform composition influences rate and extent of filament formation
@ast
Tau isoform composition influences rate and extent of filament formation
@en
type
label
Tau isoform composition influences rate and extent of filament formation
@ast
Tau isoform composition influences rate and extent of filament formation
@en
prefLabel
Tau isoform composition influences rate and extent of filament formation
@ast
Tau isoform composition influences rate and extent of filament formation
@en
P2093
P2860
P356
P1476
Tau isoform composition influences rate and extent of filament formation
@en
P2093
Haikady N Nagaraja
Jeff Kuret
P2860
P304
20711-20719
P356
10.1074/JBC.M112.364067
P407
P577
2012-04-26T00:00:00Z